Mitochondrial metabolism in hypoglossal motoneurons from mouse – implications for amyotrophic lateral sclerosis (ALS)

Bergmann, Friederike

dc.contributor.advisor	Keller, Bernhard Prof. Dr.	de
dc.contributor.author	Bergmann, Friederike	de
dc.date.accessioned	2013-01-22T15:38:43Z	de
dc.date.available	2013-01-30T23:50:58Z	de
dc.date.issued	2004-03-03	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-000D-F11F-0	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3397
dc.format.mimetype	application/pdf	de
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/	de
dc.title	Mitochondrial metabolism in hypoglossal motoneurons from mouse – implications for amyotrophic lateral sclerosis (ALS)	de
dc.type	doctoralThesis	de
dc.title.translated	Mitochondrialer Metabolismus in hypoglossalen Motoneuronen der Maus - Bedeutung für die Amyotrophe Lateral Sklerose (ALS)	de
dc.contributor.referee	Keller, Bernhard Prof. Dr.	de
dc.date.examination	2004-02-12	de
dc.subject.gok	MED 310	de
dc.description.abstracteng	Motoneurons (MNs) are selectively damaged both in human amyotrophic lateral sclerosis (ALS) and corresponding mouse models of this neurodegenerative disease. A variety of studies indicate that mitochondrial dysfunction and disruption of the cellular Ca2+ homeostasis represent critical events during the disease process. Since little is known about the involvement of mitochondria in regulation of Ca2+ levels in MNs, the first aim of this work was to define the contribution of mitochondria to the clearance of physiological type Ca2+ loads. Second, the work aimed at characterizing the cellular consequences of mitochondrial dysfunction in MNs, with particular attention to changes in electrical properties and alterations in Ca2+ homeostasis, as this may give clues to the understanding of processes involved in MN degeneration and the selective vulnerability of MNs in ALS. The contribution of mitochondria to buffering of Ca2+ loads was investigated employing acute mouse brainstem slices containing the hypoglossal motor nucleus and CCD camera based imaging techniques. It was demonstrated that in hypoglossal MNs, mitochondria constitute the dominant Ca2+ clearance mechanism accounting for buffering of ~50 % of voltage activated Ca2+ loads with amplitudes below 0.4	de
dc.contributor.coReferee	Paulus, Walter Prof. Dr.	de
dc.contributor.thirdReferee	Neher, Erwin Prof. Dr.	de
dc.subject.topic	Mathematics and Natural Science	de
dc.subject.ger	Motoneuron	de
dc.subject.ger	Mitochondrien	de
dc.subject.ger	Kalzium	de
dc.subject.ger	Neurodegeneration	de
dc.subject.ger	ALS	de
dc.subject.ger	Hypoxie	de
dc.subject.ger	Hypoglossus	de
dc.subject.ger	570 Biowissenschaften	de
dc.subject.ger	Biologie	de
dc.subject.eng	motoneuron	de
dc.subject.eng	mitochondria	de
dc.subject.eng	calcium	de
dc.subject.eng	neurodegeneration	de
dc.subject.eng	ALS	de
dc.subject.eng	hypoxia	de
dc.subject.eng	hypoglossal	de
dc.subject.bk	42.17	de
dc.subject.bk	42.15	de
dc.identifier.urn	urn:nbn:de:gbv:7-webdoc-172-0	de
dc.identifier.purl	webdoc-172	de
dc.identifier.ppn	502446064	de

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