Cell-penetrating peptide-enhanced delivery of heat shock proteins in models of neurodegeneration
Transport von Hitzeschockproteinen durch Zell-penetrierende Peptide in Modellen der Neurodegeneration
by Florian Nagel
Date of Examination:2008-04-30
Date of issue:2008-04-30
Advisor:Prof. Dr. Rüdiger Hardeland
Referee:Prof. Dr. Ralf Heinrich
Referee:Prof. Dr. Detlef Doenecke
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Description:Dissertation
Abstract
English
The hallmark of Parkinson's disease (PD) is the loss of dopaminergic (DA) neurons in the substantia nigra (SN), the depletion of striatal dopamine levels, and the presence of intraneuronal proteinaceous cytoplasmatic inclusions, termed “Lewy bodies
Keywords: Parkinson's disease; neurodegeneration; MPTP; apoptosis; neuroprotection; Tat-Hsp70; chaperone; cell penetrating peptide (CPP); protein transduction domain
Schlagwörter: Morbus Parkinson; Neurodegeneration; MPTP; Apoptose; Tat-Hsp70; Chaperon; Neuroprotektion; Zell-penetrierendes Peptid (CPP); Proteintransduktionsdomäne