Cell-penetrating peptide-enhanced delivery of heat shock proteins in models of neurodegeneration

Transport von Hitzeschockproteinen durch Zell-penetrierende Peptide in Modellen der Neurodegeneration

by Florian Nagel
Doctoral thesis
Date of Examination:2008-04-30
Date of issue:2008-04-30
Advisor:Prof. Dr. Rüdiger Hardeland
Referee:Prof. Dr. Ralf Heinrich
Referee:Prof. Dr. Detlef Doenecke
Persistent Address: http://dx.doi.org/10.53846/goediss-3451

 

 

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Abstract

English

The hallmark of Parkinson's disease (PD) is the loss of dopaminergic (DA) neurons in the substantia nigra (SN), the depletion of striatal dopamine levels, and the presence of intraneuronal proteinaceous cytoplasmatic inclusions, termed “Lewy bodies
Keywords: Parkinson's disease; neurodegeneration; MPTP; apoptosis; neuroprotection; Tat-Hsp70; chaperone; cell penetrating peptide (CPP); protein transduction domain
Schlagwörter: Morbus Parkinson; Neurodegeneration; MPTP; Apoptose; Tat-Hsp70; Chaperon; Neuroprotektion; Zell-penetrierendes Peptid (CPP); Proteintransduktionsdomäne
 
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