Expression of SLC transporters in Chronic Lymphocytic Leukaemia cells and their interaction with cytostatics

Gupta, Shivangi

dc.contributor.advisor	Pieler, Tomas Prof. Dr.	de
dc.contributor.author	Gupta, Shivangi	de
dc.date.accessioned	2013-01-22T15:49:21Z	de
dc.date.available	2013-01-30T23:50:58Z	de
dc.date.issued	2009-11-18	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-000D-F172-3	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3480
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3480
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3480
dc.format.mimetype	application/pdf	de
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/	de
dc.title	Expression of SLC transporters in Chronic Lymphocytic Leukaemia cells and their interaction with cytostatics	de
dc.type	doctoralThesis	de
dc.title.translated	Expression of SLC transporters in Chronic Lymphocytic Leukaemia cells and their interaction with cytostatics	de
dc.contributor.referee	Groß, Uwe Prof. Dr.	de
dc.date.examination	2009-10-12	de
dc.subject.dnb	500 Naturwissenschaften	de
dc.subject.gok	WA	de
dc.description.abstracteng	Chronic Lymphocytic Leukaemia, CLL, is one of the most common forms of leukaemia in the elderly. The treatment regimen determines the outcome of patients with CLL and the efficiency of this treatment is modulated by the concentration of cancer treating drugs in cancer cells. Uptake transporters of the SLC (solute carrier) family can help overcome chemoresistance by the application of transporter-specific cytostatics. In the present study, we investigated the expression of SLC transporters in six lymphoma cell lines and in CLL patient samples. Five of the six cell lines tested, as well as samples from CLL patients demonstrated a higher expression of SLC22A1 (OCT1) than in healthy lymphocytes. The uptake of the organic cation [3H]MPP into OCT1 stably transfected CHO cells was significantly inhibited by irinotecan, mitoxantrone and paclitaxel. The Ki values as determined using Dixon plot analyses were 1.71	de
dc.subject.topic	Mathematics and Natural Science	de
dc.subject.ger	SLC transporters	de
dc.subject.ger	CLL	de
dc.subject.ger	OCT1	de
dc.subject.ger	Irinotekan	de
dc.subject.ger	Paclitaxel	de
dc.subject.eng	SLC transporters	de
dc.subject.eng	CLL	de
dc.subject.eng	OCT1	de
dc.subject.eng	Irinotecan	de
dc.subject.eng	Paclitaxel	de
dc.subject.bk	42.17	de
dc.identifier.urn	urn:nbn:de:gbv:7-webdoc-2269-2	de
dc.identifier.purl	webdoc-2269	de
dc.identifier.ppn	615492584	de

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GZMB - Göttinger Zentrum für molekulare Biowissenschaften [38]
GCMB - Göttingen Center for Molecular Biosciences

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