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Variabilität des Therapieansprechens von Gemcitabin bei Pankreaskarzinom: Identifizierung relevanter Genpolymorphismen

Retrospektive Studie bei Patienten mit Pankreaskarzinom

Variability of therapy response in gemcitabine treated pancreatic carcinoma: Identifying relevant gene polymorphisms

Retrospectiv study in patients with pancreatic carcinoma

by Alexander Schaudinn
Doctoral thesis
Date of Examination:2013-01-28
Date of issue:2013-01-23
Advisor:Prof. Dr. Jürgen Brockmöller
Referee:Prof. Dr. Jürgen Brockmöller
Referee:PD Dr. Torsten Liersch
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-3369

 

 

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Abstract

English

Gene polymophisms could play an important role in the variability of therapy response in gemcitabine treated patients with pancreatic carcinoma. The retrospective study showed that a polymorphism in ENT-1, a carrier of gemcitabine, had an influence on overall survival.
Keywords: Gemcitabine; Gene Polymorphism; ENT1; Pancreatic Carcinoma
 

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