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dc.contributor.advisor Do Monte Silva Machado, Katia Karina de
dc.contributor.author Hessenthaler, Silvia de
dc.date.accessioned 2013-01-23T10:01:27Z de
dc.date.available 2013-02-04T23:50:07Z de
dc.date.issued 2013-01-23 de
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-000D-F18B-D de
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc 610 de
dc.title Neuroplastische Effekte repetitiver anodaler transkranieller Gleichstromstimulation des motorische Kortex de
dc.type doctoralThesis de
dc.title.translated Effects of neuroplasticity by repetitive anodal transcranial direct current stimulation on the human motor cortex de
dc.contributor.referee Nitsche, Michael Prof. Dr. de
dc.date.examination 2013-01-28 de
dc.subject.gok Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247) de
dc.description.abstracteng Aim of the study was to investigate the effects of repeated anodal tDCS on the human motor-cortex. tDCS is a non-invasive brain stimulation techniques, which is able to produce neuroplasticity changes in humans. So far anodal tDCS was able to produce cortical excitability-ehancement stable for one hour after the end of the stimulation in humans. We tried to induce prolonged excitability changes via spaced anodal transcranial direct current stimulation. Spaced stimulation protocols in animals or slice preparations could produce long-lasting neuroplastic alterations, stable for several hours or even days, called late-phase long-term potentiation (l-LTP). These changes in synaptic strength seem to be important for the formation of learning and memory processes. In 15 healthy subjects 13 minutes repetitive anodal tDCS of 1mA with an interstimulation interval of 0 min, 3 min, 20 min, 3 hours or 24 hours was performed. Repeated anodal tDCS with short breaks (3 min, 20 min) led – after an initial slight reduction – to an enhancement of cortical excitability which was present more than 24 hours after tDCS. The stimulation protocols making use of long breaks (3 hours, 24 hours) resulted in the formation of homeostatic plasticity changes. Doubling the stimulation duration (26 min) induced a reduction of cortical excitability, which could be abolished in a second experiment via use of calcium channel antagonist flunarizin. In conclusion, repetitive anodal tDCS with an interstimulation interval of several minutes is able to induce l-LTP-like plasticity in the human motor cortex. The results might help to improve learning protocols in humans and the efficacy of tDCS in clinical studies to optimize the treatment of patients with neuropsychiatric disease. de
dc.contributor.coReferee Keller, Bernhard Prof. Dr. de
dc.subject.eng Neuroplasticity de
dc.subject.eng Brain stimulation de
dc.subject.eng tDCS de
dc.subject.eng l-LTP de
dc.subject.eng repetitive anodal tDCS de
dc.subject.eng homeostatic plasticity de
dc.subject.eng Flunarizin de
dc.subject.eng learning and memory de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-000D-F18B-D-9 de
dc.affiliation.institute Medizinische Fakultät de
dc.description.embargoed 2013-02-04 de
dc.identifier.ppn 737346051 de

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