Neuroplastische Effekte repetitiver anodaler transkranieller Gleichstromstimulation des motorische Kortex

Hessenthaler, Silvia

dc.contributor.advisor	Do Monte Silva Machado, Katia Karina	de
dc.contributor.author	Hessenthaler, Silvia	de
dc.date.accessioned	2013-01-23T10:01:27Z	de
dc.date.available	2013-02-04T23:50:07Z	de
dc.date.issued	2013-01-23	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-000D-F18B-D	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3368
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	Neuroplastische Effekte repetitiver anodaler transkranieller Gleichstromstimulation des motorische Kortex	de
dc.type	doctoralThesis	de
dc.title.translated	Effects of neuroplasticity by repetitive anodal transcranial direct current stimulation on the human motor cortex	de
dc.contributor.referee	Nitsche, Michael Prof. Dr.	de
dc.date.examination	2013-01-28	de
dc.subject.gok	Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247)	de
dc.description.abstracteng	Aim of the study was to investigate the effects of repeated anodal tDCS on the human motor-cortex. tDCS is a non-invasive brain stimulation techniques, which is able to produce neuroplasticity changes in humans. So far anodal tDCS was able to produce cortical excitability-ehancement stable for one hour after the end of the stimulation in humans. We tried to induce prolonged excitability changes via spaced anodal transcranial direct current stimulation. Spaced stimulation protocols in animals or slice preparations could produce long-lasting neuroplastic alterations, stable for several hours or even days, called late-phase long-term potentiation (l-LTP). These changes in synaptic strength seem to be important for the formation of learning and memory processes. In 15 healthy subjects 13 minutes repetitive anodal tDCS of 1mA with an interstimulation interval of 0 min, 3 min, 20 min, 3 hours or 24 hours was performed. Repeated anodal tDCS with short breaks (3 min, 20 min) led – after an initial slight reduction – to an enhancement of cortical excitability which was present more than 24 hours after tDCS. The stimulation protocols making use of long breaks (3 hours, 24 hours) resulted in the formation of homeostatic plasticity changes. Doubling the stimulation duration (26 min) induced a reduction of cortical excitability, which could be abolished in a second experiment via use of calcium channel antagonist flunarizin. In conclusion, repetitive anodal tDCS with an interstimulation interval of several minutes is able to induce l-LTP-like plasticity in the human motor cortex. The results might help to improve learning protocols in humans and the efficacy of tDCS in clinical studies to optimize the treatment of patients with neuropsychiatric disease.	de
dc.contributor.coReferee	Keller, Bernhard Prof. Dr.	de
dc.subject.eng	Neuroplasticity	de
dc.subject.eng	Brain stimulation	de
dc.subject.eng	tDCS	de
dc.subject.eng	l-LTP	de
dc.subject.eng	repetitive anodal tDCS	de
dc.subject.eng	homeostatic plasticity	de
dc.subject.eng	Flunarizin	de
dc.subject.eng	learning and memory	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-000D-F18B-D-9	de
dc.affiliation.institute	Medizinische Fakultät	de
dc.description.embargoed	2013-02-04	de
dc.identifier.ppn	737346051	de

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Human- und Zahnmedizin [2871]

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