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Untersuchung der oligodendroglialen Membranstruktur in einem Zellkulturmodell

dc.contributor.advisorSimons, Mikael Prof. Dr.de
dc.contributor.authorFitzner, Dirkde
dc.date.accessioned2013-01-24T11:26:09Zde
dc.date.available2013-02-05T23:50:05Zde
dc.date.issued2013-01-24de
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-000D-F1A5-2de
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-3503
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-3503
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc610de
dc.titleUntersuchung der oligodendroglialen Membranstruktur in einem Zellkulturmodellde
dc.typedoctoralThesisde
dc.title.translatedAnalysis of the oligodendroglial membrane structure in a cell culture modelde
dc.contributor.refereeSimons, Mikael Prof. Dr.de
dc.date.examination2013-01-29de
dc.subject.gokWHA 000de
dc.description.abstractengDuring the process of myelination in vertebrates axons are spirally ensheathed by the oligodendroglial plasma membrane. This ensheathment consists of a highly specialized membrane with a distinct protein and especially lipid composition. Unlike other biological membranes the myelin membrane is highly enriched in galactosylceramide and cholesterol. In this study we used a neuron-glia co-culture system to analyze changes of the oligodendroglial membrane structure after contact with neurons and during myelination. Besides biochemical methods, several microscopy techniques such as stimulated emission depletion and fluorescence resonance energy transfer microscopy were applied to evaluate membrane organization on a nanoscale resolution. We were able to show a myelin basic protein dependent reorganization of the oligodendroglial membrane with a neuronal-dependent clustering of galactosylceramide in oligodendrocytes.de
dc.contributor.coRefereeRizzoli, Silvio Prof. Dr.de
dc.subject.engmyelinde
dc.subject.engoligodendrocytede
dc.subject.engmembranede
dc.subject.engmyelin basic proteinde
dc.subject.engmyelinationde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-000D-F1A5-2-2de
dc.affiliation.instituteMedizinische Fakultätde
dc.description.embargoed2013-02-05de
dc.identifier.ppn737346213de


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