Untersuchung der oligodendroglialen Membranstruktur in einem Zellkulturmodell

Fitzner, Dirk

dc.contributor.advisor	Simons, Mikael Prof. Dr.	de
dc.contributor.author	Fitzner, Dirk	de
dc.date.accessioned	2013-01-24T11:26:09Z	de
dc.date.available	2013-02-05T23:50:05Z	de
dc.date.issued	2013-01-24	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-000D-F1A5-2	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3503
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3503
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	Untersuchung der oligodendroglialen Membranstruktur in einem Zellkulturmodell	de
dc.type	doctoralThesis	de
dc.title.translated	Analysis of the oligodendroglial membrane structure in a cell culture model	de
dc.contributor.referee	Simons, Mikael Prof. Dr.	de
dc.date.examination	2013-01-29	de
dc.subject.gok	WHA 000	de
dc.description.abstracteng	During the process of myelination in vertebrates axons are spirally ensheathed by the oligodendroglial plasma membrane. This ensheathment consists of a highly specialized membrane with a distinct protein and especially lipid composition. Unlike other biological membranes the myelin membrane is highly enriched in galactosylceramide and cholesterol. In this study we used a neuron-glia co-culture system to analyze changes of the oligodendroglial membrane structure after contact with neurons and during myelination. Besides biochemical methods, several microscopy techniques such as stimulated emission depletion and fluorescence resonance energy transfer microscopy were applied to evaluate membrane organization on a nanoscale resolution. We were able to show a myelin basic protein dependent reorganization of the oligodendroglial membrane with a neuronal-dependent clustering of galactosylceramide in oligodendrocytes.	de
dc.contributor.coReferee	Rizzoli, Silvio Prof. Dr.	de
dc.subject.eng	myelin	de
dc.subject.eng	oligodendrocyte	de
dc.subject.eng	membrane	de
dc.subject.eng	myelin basic protein	de
dc.subject.eng	myelination	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-000D-F1A5-2-2	de
dc.affiliation.institute	Medizinische Fakultät	de
dc.description.embargoed	2013-02-05	de
dc.identifier.ppn	737346213	de

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Human- und Zahnmedizin [3108]

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