Show simple item record

Studies of cultured neuronal networks using light activated ion channels and pumps

dc.contributor.advisorWolf, Fred Prof.
dc.contributor.authorEl Hady, Ahmedde
dc.titleStudies of cultured neuronal networks using light activated ion channels and pumpsde
dc.contributor.refereeStühmer, Walter Prof.
dc.description.abstractengIn the presented thesis work, an “Optical Network Electrophysiology “ system that combines optical stimulation using optogenetic tools and multisite neuronal recording using microelectrode arrays was developed and its applicability to address questions related to neuronal network dynamics was demonstrated. The system was used to modify the intrinsic collective dynamics of a cultured neuronal network potentially maximizing spike synchronization using mild whole field photostimulation. It offers an attractive alternative to stimulation paradigms that externally control neuronal networks. Another application of the system was to drive neurons in a naturalistic in-vivo like fashion where fluctuating light waveforms where used to put neurons in “fluctuation driven regime”. This regime is crucial to characterize basic computational properties of neurons such as frequency-input curves, spike triggered average and correlation
dc.contributor.coRefereeGeisel, Theo Prof.
dc.subject.engMultielectrode arraysde
dc.subject.engNetwork electrophysiologyde
dc.subject.engFluctuation driven regimede
dc.subject.engNetwork-level plasticityde
dc.affiliation.instituteGöttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)de
dc.subject.gokfullBiologie (PPN619462639)de

Files in this item


This item appears in the following Collection(s)

Show simple item record