In vitro effects of periodontopathic bacteria on the proliferation and osteogenic potential of human mesenchymal stem cells

Baligh, Ahmed

dc.contributor.advisor	Miosge, Nicolai Prof. Dr.	de
dc.contributor.author	Baligh, Ahmed	de
dc.date.accessioned	2013-03-06T10:11:23Z	de
dc.date.available	2013-03-13T23:50:05Z	de
dc.date.issued	2013-03-06	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-000E-0B5A-C	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3766
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	In vitro effects of periodontopathic bacteria on the proliferation and osteogenic potential of human mesenchymal stem cells	de
dc.type	doctoralThesis	de
dc.contributor.referee	Miosge, Nicolai Prof. Dr.	de
dc.date.examination	2013-03-05	de
dc.description.abstracteng	Periodontitis is a bacterial biofilm induced inflammatory disease that results in the destruction of the periodontal components including the destruction of the PDL, cementum, gingiva, and alveolar bone. It has been found that periodontal regeneration by conventional methods, for example, scaling, root planning, bone grafts, and barrier membranes might be effective in some cases. However, these conventional methods have shown some limitations with certain extensive cases. That is the main reason of the great concern about periodontal regeneration aided by the use of stem cells. This study mainly concentrates on the immortalized human mesenchymal stem cells (hMSCs), and their ability to withstand culturing and incubation with the bacteria that are involved in periodontitis, namely, Actinobacillus actinomycetemcomitans, and Eikenella corrodens, in order to elucidate their effects on the behavior of the hMSCs regarding their stemness, degree of osteogenic differentiation, and proliferation capacity.	de
dc.contributor.coReferee	Lüder, Carsten Prof. Dr.	de
dc.contributor.thirdReferee	Guan-Schmidt, Kaomei PD Dr.	de
dc.subject.eng	periodontitis	de
dc.subject.eng	immortalized human mesenchymal stem cells	de
dc.subject.eng	periodontopathic bacteria	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-000E-0B5A-C-4	de
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.description.embargoed	2013-03-13	de
dc.identifier.ppn	750587849

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Human- und Zahnmedizin [2872]

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