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Untersuchung von Proteomveränderungen im Synaptosom von Patienten mit sporadischer Creutzfeldt-Jakob-Krankheit

dc.contributor.advisorCrozier, Thomas Prof. Dr. Dr.de
dc.contributor.authorNowak, Martinde
dc.date.accessioned2013-03-07T10:16:08Zde
dc.date.available2013-04-04T22:50:04Zde
dc.date.issued2013-03-07de
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-000E-0B77-Ade
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-3760
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc610de
dc.titleUntersuchung von Proteomveränderungen im Synaptosom von Patienten mit sporadischer Creutzfeldt-Jakob-Krankheitde
dc.typedoctoralThesisde
dc.title.translatedMisfolded Prion Form-specific Synaptic Proteome Alterations in sporadic Creutzfeldt-Jakob Diseasede
dc.contributor.refereeZerr, Inga Prof. Dr.de
dc.date.examination2013-03-27de
dc.description.abstractengSporadic Creutzfeldt-Jakob disease (sCJD) is characterized by wide clinical and pathological variability. This heterogeneity might be caused by the involvement of different molecular pathways depending on the prion agent type (or prion strain), which is thought to be determined by prion protein conformation. In these studies we show altered synaptic proteome patterns in MM1- and VV2-sCJD subtypes. Analysis of 2D maps revealed that 40 various protein spots were differentially expressed in sCJD in at least one sCJD subtype when compared to age-matched controls. Among them, 29 protein spots could be identified what corresponded to 23 different proteins. Surprisingly, only one protein displayed common dysregulation in both subtypes. However, a strong tendency to common dysregulation could be observed for another eight proteins. Remaining proteins displayed significant subtype-specific dysregulation. Interestingly, many prion-dysregulated proteins were identified that were previously associated with synaptic structure and activity, mitochondrial function and calcium metabolism or AD pathophysiology. de
dc.contributor.coRefereeDresbach, Thomas Prof. Dr.de
dc.subject.gerCreutzfeldtde
dc.subject.gersporadischde
dc.subject.gerSynaptosomde
dc.subject.gerProteomde
dc.subject.engCreutzfeldtde
dc.subject.engsporadicde
dc.subject.engsynapticde
dc.subject.engproteomede
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-000E-0B77-A-9de
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.description.embargoed2013-04-04de
dc.identifier.ppn750587881


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