Site-selective ruthenium-catalyzed C-H bond functionalization was achieved under carboxylate-assistance. Direct ortho- and meta-alkylations on various arenes with unactivated alkyl halides has been accomplished and unprecedented oxidative annulations for a step- and atom-economic heterocycle-synthesis was developed.
Keywords: C-H Bond Functionalization; Ruthenium-Catalyzed; meta-Functionalization; Direct Alkylation; Oxidative Annulation; Site-Selective Alkylation; Homogeneous Catalysis
