Carboxylate-Assisted Ruthenium-Catalyzed C-H Bond meta-Alkylations and Oxidative Annulations

Carboxylate-Assisted Ruthenium-Catalyzed C-H Bond meta-Alkylations and Oxidative Annulations

Nora Hofmann

Doctoral thesis

Date of Examination: 2013-03-07

Date of issue: 2013-03-26

Advisor: Ackermann, Lutz Prof. Dr.

Referee: Ackermann, Lutz Prof. Dr.

Referee: Stalke, Dietmar Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-0014-D4A4-1

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Abstract

English

Site-selective ruthenium-catalyzed C-H bond functionalization was achieved under carboxylate-assistance. Direct ortho- and meta-alkylations on various arenes with unactivated alkyl halides has been accomplished and unprecedented oxidative annulations for a step- and atom-economic heterocycle-synthesis was developed.

Keywords: C-H Bond Functionalization; Ruthenium-Catalyzed; meta-Functionalization; Direct Alkylation; Oxidative Annulation; Site-Selective Alkylation; Homogeneous Catalysis