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Charakterisierung von Ratten-Myofibroblasten des Gastrointestinaltrakts und der Leber unter Berücksichtigung mikroskopischer und molekularbiologischer Aspekte

dc.contributor.advisorWilting, Jörg Prof. Dr.de
dc.contributor.authorLührs, Fabiande
dc.date.accessioned2013-04-30T10:18:02Zde
dc.date.available2013-05-07T22:50:05Zde
dc.date.issued2013-04-30de
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0015-A384-3de
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-3819
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc610de
dc.titleCharakterisierung von Ratten-Myofibroblasten des Gastrointestinaltrakts und der Leber unter Berücksichtigung mikroskopischer und molekularbiologischer Aspektede
dc.typedoctoralThesisde
dc.title.translatedCharacterization of rat myofibroblasts of the gastrointestinal tract and liver, taking into account microscopic and molecular biological aspectsde
dc.contributor.refereeZeisberg, Michael Prof. Dr.de
dc.date.examination2013-04-30de
dc.description.abstractengMyofibroblasts (MF) are connective tissue cells with properties of smooth muscle cells and fibroblasts. In contrast to normal fibroblasts they express alpha smooth muscle actin (α-SMA) and Thy-1. MF have influence on the growth and differentiation of epithelial cells, as well as the modulation of the immune response. The aim of this study was to analyze the gastrointestinal MF and the MF of the liver of healthy rats. The MF were first cultivated and afterwards identified and characterized upon ultrastructural and molecular markers. Besides the many similarities in terms of morphology, staining behavior and ultrastructure, the differences found by us in the gene expression analysis suggests an organ-specific function of the different MF.de
dc.contributor.coRefereeOppermann, Martin Prof. Dr.de
dc.subject.engMyofibroblastde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0015-A384-3-4de
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullInnere Medizin - Allgemein- und Gesamtdarstellungen (PPN619875747)de
dc.description.embargoed2013-05-07de
dc.identifier.ppn746434502de


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