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Die Auswirkungen von Nikotin und eines Nikotinentzugs auf polysomnografische und neuroendokrine Parameter

Eine systematische Übersichtsarbeit

dc.contributor.advisorRodenbeck, Andrea Prof. Dr.de
dc.contributor.authorLandgraf, Clarade
dc.date.accessioned2013-05-10T08:14:59Zde
dc.date.available2013-05-21T22:50:05Zde
dc.date.issued2013-05-10de
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0018-00A8-Cde
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-3833
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-3833
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-3833
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc610de
dc.titleDie Auswirkungen von Nikotin und eines Nikotinentzugs auf polysomnografische und neuroendokrine Parameterde
dc.title.alternativeEine systematische Übersichtsarbeitde
dc.typedoctoralThesisde
dc.title.translatedThe effects of nicotine and its withdrawal on sleep and neuroendocrine parametersde
dc.contributor.refereeRaupach, Tobias PD Dr.de
dc.date.examination2013-05-14de
dc.description.abstractengNicotine and its withdrawal influence objective markers of sleep and neuroendocrine parameters. This systematic review compares current studies, investigating the effects of nicotine and its withdrawal on sleep, measured by polysomnography or actigraphy and cortisol and dopamine levels. In animal studies, nicotine had a dose-dependent effect on sleep, namely lower doses reduced REM-sleep and higher doses promoted wakefulness. Nonsmokers showed a reduction of REM-sleep after nicotine administration, while in depressed nonsmokers an improvement in sleep quality and depression was observed. The first days of withdrawal in smokers caused an increased fragmentation of sleep, which could be reduced by using nicotine replacement therapy. The only publication which studied the withdrawal a longer time, showed an increase of REM-sleep and a decrease of total sleep time. The parameters of the dopaminergic system were stable during the first hours of abstinence, but in a long-term study an increase in dopamine receptors was observed. Nicotine also led to an increased secretion of hormones of the HPA axis. During nicotine withdrawal, decreased concentrations of cortisol were measured. A lower cortisol concentration during abstinence predicted higher severty of withdrawal symptoms and may be a predictor of relapse.de
dc.contributor.coRefereeStraube, Sebastian PD Dr.de
dc.subject.engNicotinede
dc.subject.engSleepde
dc.subject.engCortisolde
dc.subject.engDopaminede
dc.subject.engWithdrawalde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0018-00A8-C-4de
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullEndokrinologie (PPN619875836)de
dc.subject.gokfullSchlafmedizinde
dc.subject.gokfullSuchtmedizinde
dc.description.embargoed2013-05-21de
dc.identifier.ppn746434693de


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