Retrospektive Analyse von Diagnostik, Klinik und Verlauf bei Patienten mit Vena-cava-superior-Syndrom (obere Einflussstauung)

Bertram, Nick

dc.contributor.advisor	Trümper, Lorenz Prof. Dr.
dc.contributor.author	Bertram, Nick
dc.date.accessioned	2015-01-27T09:08:36Z
dc.date.available	2015-03-13T23:50:10Z
dc.date.issued	2015-01-27
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0022-5D98-3
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4882
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	Retrospektive Analyse von Diagnostik, Klinik und Verlauf bei Patienten mit Vena-cava-superior-Syndrom (obere Einflussstauung)	de
dc.type	doctoralThesis	de
dc.title.translated	A retrospective analysis of the diagnosis, treatment and course in patients with superior vena cava syndrome	de
dc.contributor.referee	Wolff, Hendrik PD Dr.
dc.date.examination	2015-03-04
dc.description.abstracteng	Superior vena cava syndrome (SVCS) is caused by a compression of the superior vena cava and represents an important oncologic emergency. The aim of this retrospective study was to investigate if there are differences in diagnosis, clinical features, course and outcome in patients with SVCS depending on whether a patient was admitted and treated on a weekday or at a weekend at the University Hospital in Göttingen due to different staff resources. 124 patients were identified with SVCS caused by malignancy from the hospital’s database for the years 1992 to 2011 and they were separated into two groups depending on their admission day. Among the 124 cases, the following entities led to SVCS: small cell lung cancer (SCLC) in 28,2%, non-small cell lung cancer (NSCLC) in 25,0%, non-Hodgkin’s lymphoma (NHL) in 25,0%, metastases of other malignant tumors in 19,4% and Hodgkin's disease in 2,4% of all cases. Ten of these patients had a recurrence of a previous malignant disease. In all patients in whom malignant cause of the present SVCS was not yet known an emergency histology was done and subsequently a treatment decision was made. The histology and treatment decision were made regardless of whether the patient had been taken to the hospital on a weekday or at the weekend. None of the patients in this study died due to SVCS. The analysis showed that the difference in mortality rates between patients of the weekday group (12.3%) and weekend group (11.6%) was minimal. There was also no difference found in choice of treatment (chemotherapy, radiation, radiochemotherapy, palliative treatment or no treatment) between the two groups. Apart from the comparison of the above groups, the study also found that relapsed patients had a worse outcome compared to the other patients. The same was seen in patients for whom no emergency histology was done and in which the underlying malignant disease was already known at admission to the hospital with SVCS. Furthermore, a comparison of the response rates of malignant entities and their treatment modalities described in the literature with the ones of patients in this study who also suffered from SVCS was undertaken. It showed that lower remission rates were achieved in patients with SVCS.	de
dc.contributor.coReferee	Mausberg, Rainer Prof. Dr.
dc.subject.ger	Vena cava superior Syndrom	de
dc.subject.ger	VCSS	de
dc.subject.ger	obere Einflussstauung	de
dc.subject.ger	Morbus Hodgkin	de
dc.subject.ger	Kleinzelliges Lungenkarzinom	de
dc.subject.ger	Non-Hodgkin-Lymphom	de
dc.subject.ger	nicht kleinzelliges Lungenkarzinom	de
dc.subject.ger	SCLC	de
dc.subject.ger	NSCLC	de
dc.subject.ger	Metastasen	de
dc.subject.eng	Superior vena cava syndrome	de
dc.subject.eng	SVCS	de
dc.subject.eng	superior vena cava	de
dc.subject.eng	small cell lung cancer	de
dc.subject.eng	non-small cell lung cancer	de
dc.subject.eng	SCLC	de
dc.subject.eng	NSCLC	de
dc.subject.eng	non-Hodgkin’s lymphoma	de
dc.subject.eng	metastases	de
dc.subject.eng	Hodgkin's disease	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5D98-3-8
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.description.embargoed	2015-03-13
dc.identifier.ppn	816636982

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