| dc.contributor.advisor | Hallatschek, Oskar Dr. | |
| dc.contributor.author | Stiewe, Fabian | |
| dc.date.accessioned | 2015-02-03T10:29:39Z | |
| dc.date.available | 2015-02-03T10:29:39Z | |
| dc.date.issued | 2015-02-03 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0022-5DA1-B | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-4902 | |
| dc.language.iso | eng | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
| dc.subject.ddc | 571.4 | de |
| dc.title | The Level of Noise Controls the Efficiency of Natural Selection in Growing Biofilms | de |
| dc.type | doctoralThesis | de |
| dc.contributor.referee | Schmidt, Christoph F. Prof. Dr. | |
| dc.date.examination | 2014-12-11 | |
| dc.description.abstracteng | Many microbes live in biofilms, which are spatially structured populations.
During adaptation to a new environment, beneficial mutations occur, and some
of them spread through the population. Others go extinct due to noise in the life
cycle and reproduction process. This noise is called genetic drift. Growing biofilms
are an example of populations undergoing a range expansion. The level of noise
in growing biofilms differs strongly between species. However, the effect of
these different noise levels on the establishment of beneficial mutations has not yet
been quantified. Here we show, that the observed differences in noise level indeed
lead to large differences in the establishment rates of beneficial mutations. We
found establishment rates of S. cerevisiae and spherical E.coli strains to be 1–2
orders of magnitude larger than establishment rates of rod-like strains of E. coli.
Furthermore we observed that the noise level can be tuned via growth temperature,
and that the establishment rates measured at different temperatures are consistent
with the respective noise levels. Our results suggest that the efficiency of natural
selection in biofilms strongly depends on the species and growth conditions. The
method presented in this study can be used to test the dependence of establishment
rates on other parameters and for many microbial species easily. | de |
| dc.contributor.coReferee | Katifori, Eleni Dr. | |
| dc.subject.eng | Adaptation | de |
| dc.subject.eng | Biofilms | de |
| dc.subject.eng | Genetic Drift | de |
| dc.subject.eng | Spatial Structure | de |
| dc.subject.eng | Range Expansions | de |
| dc.subject.eng | Natural Selection | de |
| dc.subject.eng | Establishment of Mutations | de |
| dc.subject.eng | Microbial Evolution | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5DA1-B-5 | |
| dc.affiliation.institute | Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB) | de |
| dc.subject.gokfull | Biologie (PPN619462639) | de |
| dc.identifier.ppn | 817287191 | |