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Identifizierung von Biomarkern für die Prognose der Gemcitabin-Therapie beim Pankreaskarzinom: RNA-, DNA- und Immunhistochemische- Analysen

dc.contributor.advisorBrockmöller, Jürgen Prof. Dr.
dc.contributor.authorZimmer, Christian
dc.date.accessioned2015-02-06T13:48:34Z
dc.date.available2015-08-11T22:50:12Z
dc.date.issued2015-02-06
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0022-5DAA-A
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-4903
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc610de
dc.titleIdentifizierung von Biomarkern für die Prognose der Gemcitabin-Therapie beim Pankreaskarzinom: RNA-, DNA- und Immunhistochemische- Analysende
dc.typedoctoralThesisde
dc.title.translatedIdentification of biomarkers for the prognosis in gemcitabine treated pancreatic cancer: RNA-, DNA- and immunhistochemical- analysisde
dc.contributor.refereeEllenrieder, Volker Prof. Dr.
dc.date.examination2015-02-11
dc.description.abstractengOne aim of this study was to investigate the associations of genetic polymorphisms in the genes involved in gemcitabine pathways and the cinical outcome of patients with pancreatic ductal adenocarcinoma. A nucleoitide polymorphism in ENT1 (SLC29A1) gene, a transmembrane transporter of gemcitabine, had an influence on overall survival. Based on immunhistochemical analysis it could be shown, that patients with a high ENT1 protein expression benefits from a gemcitabin therapy. de
dc.contributor.coRefereeSchön, Margarete Prof. Dr.
dc.subject.gerGemcitabinde
dc.subject.gerPankreaskarzinomde
dc.subject.gerENT1de
dc.subject.gergenetische Polymorphismende
dc.subject.gerNukleosid Transporterde
dc.subject.engpankreatic cancerde
dc.subject.enggemcitabin treatmentde
dc.subject.engent1de
dc.subject.enggenetic polymorphismsde
dc.subject.engnucleoside transporterde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0022-5DAA-A-4
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullPharmakologie / Toxikologie / Pharmakotherapie - Allgemein- und Gesamtdarstellungen (PPN61987550X)de
dc.subject.gokfullInnere Medizin - Allgemein- und Gesamtdarstellungen (PPN619875747)de
dc.subject.gokfullChirurgie - Allgemein- und Gesamtdarstellungen (PPN619875968)de
dc.description.embargoed2015-08-11
dc.identifier.ppn817665676


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