dc.contributor.advisor | Brockmöller, Jürgen Prof. Dr. | |
dc.contributor.author | Zimmer, Christian | |
dc.date.accessioned | 2015-02-06T13:48:34Z | |
dc.date.available | 2015-08-11T22:50:12Z | |
dc.date.issued | 2015-02-06 | |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0022-5DAA-A | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-4903 | |
dc.language.iso | deu | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Identifizierung von Biomarkern für die Prognose der Gemcitabin-Therapie beim Pankreaskarzinom: RNA-, DNA- und Immunhistochemische- Analysen | de |
dc.type | doctoralThesis | de |
dc.title.translated | Identification of biomarkers for the prognosis in gemcitabine treated pancreatic cancer: RNA-, DNA- and immunhistochemical- analysis | de |
dc.contributor.referee | Ellenrieder, Volker Prof. Dr. | |
dc.date.examination | 2015-02-11 | |
dc.description.abstracteng | One aim of this study was to investigate the associations of genetic polymorphisms in the genes involved in gemcitabine pathways and the cinical outcome of patients with pancreatic ductal adenocarcinoma. A nucleoitide polymorphism in ENT1 (SLC29A1) gene, a transmembrane transporter of gemcitabine, had an influence on overall survival. Based on immunhistochemical analysis it could be shown, that patients with a high ENT1 protein expression benefits from a gemcitabin therapy. | de |
dc.contributor.coReferee | Schön, Margarete Prof. Dr. | |
dc.subject.ger | Gemcitabin | de |
dc.subject.ger | Pankreaskarzinom | de |
dc.subject.ger | ENT1 | de |
dc.subject.ger | genetische Polymorphismen | de |
dc.subject.ger | Nukleosid Transporter | de |
dc.subject.eng | pankreatic cancer | de |
dc.subject.eng | gemcitabin treatment | de |
dc.subject.eng | ent1 | de |
dc.subject.eng | genetic polymorphisms | de |
dc.subject.eng | nucleoside transporter | de |
dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5DAA-A-4 | |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Pharmakologie / Toxikologie / Pharmakotherapie - Allgemein- und Gesamtdarstellungen (PPN61987550X) | de |
dc.subject.gokfull | Innere Medizin - Allgemein- und Gesamtdarstellungen (PPN619875747) | de |
dc.subject.gokfull | Chirurgie - Allgemein- und Gesamtdarstellungen (PPN619875968) | de |
dc.description.embargoed | 2015-08-11 | |
dc.identifier.ppn | 817665676 | |