dc.contributor.advisor | Ackermann, Lutz Prof. Dr. | |
dc.contributor.author | Zhu, Yingjun | |
dc.date.accessioned | 2015-03-03T09:04:11Z | |
dc.date.available | 2015-03-03T09:04:11Z | |
dc.date.issued | 2015-03-03 | |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0022-5DDA-D | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-4957 | |
dc.language.iso | eng | de |
dc.publisher | Niedersächsische Staats- und Universitätsbibliothek Göttingen | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject.ddc | 540 | de |
dc.title | Sustainable Strategies for Site-Selective C–H Functionalizations of N-Heterocycles | de |
dc.type | doctoralThesis | de |
dc.contributor.referee | Ackermann, Lutz Prof. Dr. | |
dc.date.examination | 2015-02-12 | |
dc.description.abstracteng | The development of sustainable strategies for the synthesis of highly functionalized N-containing heterocycles is of great importance for the preparation of pharmaceuticals, agrochemicals and functional materials. Thus, the focus of the present work was set on the construction of a variety of heterocyclic frameworks through palladium-catalyzed or metal-free direct C−H functionalizations. At first, the substrate scope for the direct C–H alkynylation of oxazoles with gem-dichloroalkenes was explored. Subsequeutly, diaryliodonium tosylates were used for metal-free C2-arylations of indoles bearing the acetamide functionality at the C3 position. Meanwhile, the challenging metal-free arylation-cyclization cascade reaction was elaborated by blocking the C2 position of indoles, delivering C3-aryl pyrroloindolones. Thereafter, The approach for the metal-free C−H arylations of indoles was further applied to peptides involving the indolylacetyl moiety as a tag at the N-terminus. Finally, The late-stage modification of tryptophan-containing peptides was accomplished through the palladium-catalyzed C–H arylation. | de |
dc.contributor.coReferee | Stalke, Dietmar Prof. Dr. | |
dc.subject.eng | direct C−H functionalization | de |
dc.subject.eng | alkynylation of oxazoles | de |
dc.subject.eng | arylation of indoles | de |
dc.subject.eng | late-stage arylation of tryptophan-containing peptides | de |
dc.subject.eng | metal-free synthesis of pyrroloindolones | de |
dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5DDA-D-7 | |
dc.affiliation.institute | Fakultät für Chemie | de |
dc.subject.gokfull | Chemie (PPN62138352X) | de |
dc.identifier.ppn | 819364053 | |