• Deutsch
    • English
  • English 
    • Deutsch
    • English
  • Login
Item View 
  •   Home
  • Zentren & Graduiertenschulen
  • GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften
  • Item View
  •   Home
  • Zentren & Graduiertenschulen
  • GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften
  • Item View
JavaScript is disabled for your browser. Some features of this site may not work without it.

The influence of common infections on clinical course and neurodegeneration in an animal model of multiple sclerosis

by Prateek Kumar
Doctoral thesis
Date of Examination:2014-09-07
Date of issue:2015-03-05
Advisor:Prof. Dr. Mathias Bähr
Referee:Prof. Dr. Mikael Simons
Referee:Prof. Dr. Klaus-Armin Nave
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-4967

 

 

Files in this item

Name:PhD thesis_Prateek kumar.pdf
Size:2.04Mb
Format:PDF
Description:PhD thesis_main article
ViewOpen

The following license files are associated with this item:


Abstract

English

The course of Multiple Sclerosis (MS), a chronic autoimmune disease, can be influenced by systemic infections. The common notion is that bacterial infections worsen disease symptoms and lead to enhanced neurodegeneration. However, the underlying biological mechanisms by which bacterial infections may lead to neurodegeneration in MS are complex and poorly understood. Here, we assessed the disease-modulating effect of an acute Escherichia coli and a chronic Staphylococcus aureus infection on the clinical course and the extent of neurodegeneration in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. In this study, we did not observe any disease modulating effect of acute E. coli infection on EAE when infection was induced in both the preclinical and in the clinical phase of the disease. However, we observed that local application of S. aureus in the preclinical phase of the disease induced a chronic systemic inflammatory response with increased in T- and B-cell counts as well as systemic production of pro-inflammatory cytokines. Unexpectedly, the infection with S. aureus completely prevented the development of clinical EAE. Moreover, it markedly decreased the extent of inflammatory infiltrates and demyelination of the optic nerve and increased the number of surviving retinal neurons. Using a S. aureus strain deficient for the extracellular adherence protein (Eap) we identified this protein to be at least partly responsible for the inhibitory effect of S. aureus infection on autoimmune inflammation of the central nervous system. Thus our results show for the first time a beneficial effect of a chronic bacterial infection on neurodegeneration in EAE and open the avenue for the design of new neuroprotective therapy in MS.
Keywords: Infection; Experimental autoimmune encephalomyelitis; Neurodegeneration
 

Statistik

Publish here

Browse

All of eDissFaculties & ProgramsIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesTypeThis FacultyIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesType

Help & Info

Publishing on eDissPDF GuideTerms of ContractFAQ

Contact Us | Impressum | Cookie Consents | Data Protection Information
eDiss Office - SUB Göttingen (Central Library)
Platz der Göttinger Sieben 1
Mo - Fr 10:00 – 12:00 h


Tel.: +49 (0)551 39-27809 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
ediss_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]
Göttingen State and University Library | Göttingen University
Medicine Library (Doctoral candidates of medicine only)
Robert-Koch-Str. 40
Mon – Fri 8:00 – 24:00 h
Sat - Sun 8:00 – 22:00 h
Holidays 10:00 – 20:00 h
Tel.: +49 551 39-8395 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
bbmed_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]