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Der Einfluss von Sexual- und Phytohormonen sowie Ganz-Körper-Vibration auf die Wundheilung des osteoporotischen Knochens der männlichen Ratte

dc.contributor.advisorWiese, Karl Günter Prof. Dr. Dr.
dc.contributor.authorSzentmiklossy von Primocz, Johannes Pal
dc.date.accessioned2014-02-28T12:52:31Z
dc.date.available2014-04-07T22:50:04Z
dc.date.issued2014-02-28
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0022-5E45-6
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-4381
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-4381
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc610de
dc.titleDer Einfluss von Sexual- und Phytohormonen sowie Ganz-Körper-Vibration auf die Wundheilung des osteoporotischen Knochens der männlichen Rattede
dc.typedoctoralThesisde
dc.title.translatedThe influence of sexual and phytohormones as well as whole-body vibration on wound healing of osteoporotic bone of the male ratde
dc.contributor.refereeWiese, Karl Günter Prof. Dr. Dr.
dc.date.examination2014-03-26
dc.description.abstractengDue to a longer life expectancy, the morbidity rate of osteoporosis increases not only for females, but also for male patients. Therapeutic and preventive approaches, such as the substitution of the sexual hormones Dihydrotestosteron (DHT) and 17β-Estradiol (E2) and the phytohormones Genistein (GEN) and Equol (EQ) are mainly studied in combination with female osteoporosis. The intention of this dissertation was to examine, whether the donation of the mentioned hormones and hormone-substitutes positively influences the bone of the orchiectomized (orx) rats to prevent osteoporosis. Furthermore the influence of whole-body-vibration (GKV) and bone-healing to the bone-remodeling was to be investigated. For this study the cortical and the cancellous bone, the epiphyseal plate and the articular cartilage of the tibia have been analyzed histologically. The tibial bone of the orx SD-rats was used as a model. The 180 animals were divided into 5 treatment groups and one control group. The first group was only fed with soja free food, whereas the food of the other groups were supplemented with DHT, E2, GEN or EQ. Furthermore the groups have been separated into three different series, which were exposed to vibrations for four weeks. One half of the animal of the third series has additionally been vibrated a second time for a period of four weeks. Next to one orchidectomized group without vibration and trepanation (SF group) there was one control group for each set of treated laboratory rats. The animals of the control group have been fed with soja free food and they were exposed to a vibration and trepanation. The donation of hormones causes different affects to the cortical and the cancellous bone, the epiphyseal plate and the articular cartilage of the tibia. As a result of trepanation the trabecels of the orx rats increase in size and show additional branches. On the other hand the GKV caused an incrementing cortical-thickness and a thinning of the trabecular bone. The GKV-induced gain of cortical-thickness is supressed by DHT and E2 donation. Unlike the sexual hormones, the donation of EQ, especially that of GEN in combination with the GKV significantly increases the cortical-thickness of the rats. In contrast to GEN, EQ seems not to preserve the cortical bone at the level of the SF-control group without GKV. To the cancellous bone, the combination of E2 and GKV causes a rarification of the trabecels, while a combination of DHT and GKV causes a reduction of trabecels. The exclusive substitution of sexual hormones seems to cause larger and more frequently branched trabecels at the orx rat, then a plain SF-diet. The exclusive donation of phytohormones also induces larger and more frequently branched trabecels at the orx rats. The combination of GKV and GEN-donation leads to a decreasing trabecel-size, with an increasing trabecel-number. Together with GKV, the donation of EQ leads to a significant size increment of the trabecels, as well as a gain of trabecel-branches. In this combination only the donation of EQ has a positive influence to the cancellous bone. Independent of the donation of hormones and hormone substitutes, the thickness of the epiphyseal plate decreased in all series of laboratory rats. The E2-substitution definitely induces the strongest decrease of epiphyseal plate-thickness. The GKV has no influence on the thickness of the epiphyseal plate. All tested hormones and hormone substitutes showed no distinct protective influence on the articular cartilage of the tibia compared to the SF group. The GKV seems to have the strongest protective function for the articular cartilage. In summary, the donation of the phytohormon EQ in combination with the whole-body-vibration seems to be the most reliable therapeutic or preventive approach to avoid male osteoporosis.de
dc.contributor.coRefereeTezval, Mohammad PD Dr.
dc.subject.engosteoporosisde
dc.subject.engdihydrotestosteronde
dc.subject.engEstrogende
dc.subject.enggenisteinde
dc.subject.engequolde
dc.subject.engmale ratde
dc.subject.engwhole-body-vibrationde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0022-5E45-6-2
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.subject.gokfullZahn-, Mund- und Kieferheilkunde - Allgemein- und Gesamtdarstellungen (PPN619876360)de
dc.description.embargoed2014-04-07
dc.identifier.ppn779676858


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