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Klinische Querschnittstudie zur möglichen Assoziation rheumatoider Arthritis und parodontaler Gesundheit - Ein Vergleich zwischen Patienten mit rheumatoider Arthritis und allgemein Gesunden

dc.contributor.advisorZiebolz, Dirk PD Dr.
dc.contributor.authorJäger, Jatina
dc.titleKlinische Querschnittstudie zur möglichen Assoziation rheumatoider Arthritis und parodontaler Gesundheit - Ein Vergleich zwischen Patienten mit rheumatoider Arthritis und allgemein Gesundende
dc.title.translatedPeriodontal healthiness of patients with rheumatoid arthritis - a clinical cross-sectional studyde
dc.contributor.refereePatschan, Susann PD Dr.
dc.description.abstractengThe objective of this clinical cross-sectional study was to analyse rheumatoid arthritis patients (RA) in regard to their periodontal healthiness and compare it with healthy, non rheumatoid arthritis patients. Diagnosed and treated RA-patients were considered for the study. A control group (C) of healthy individuals was created matched to their age, gender and smoking behavior. Questionaires on general health and medication were applied from all participants . In addition, in all RA-patients the disease duration, disease activity by Disease Activity Score using 28 joints (DAS-28), the rheumatoid factor and anti citrullinated protein antibodies were noted. All participants had an oral examination included dental finding (Decayed, Missing, Filled Teeth-Index, DMF-T), gingival inflamation (Papilla Bleeding Index, PBI) and periodontal status on six sites per tooth assessing probing pocket depth (PD), bleeding on probing (BOP), missing teeth and clinical attachment loss (CAL) were measured. The classification of the periodontal disease was established based on PD and/or CAL in healthy/mild, moderate or pronounced periodontitis. Statistical analysis made by Cochran-Armitage-Test for Trend, Wilcoxon Two Sample Test and Fisher`s Exact Test. The significance level was α=5%. In total, 103 RA-patients (55,5±11,0 Years, female=58, average duration of disease: 11,1±15,9 Years) and 104 healthy controls (56,7±11,9 Years, female=68) were considered. DMF-T (RA: 17,6±6,1 / C: 16,0 ± 6,5) and PBI (RA: 0,10±0,18 / C 0,08±0,18) didn`t show any significant differences (p>0,05); however, RA-patients had on average one tooth less (missing-teeth: RA: 5,3±5,4 / C: 4,2±4,5). The average PD (RA: 3,2±1,1 / C: 3,4±1,3) and CAL (RA: 3,4±1,3 / C: 3,5±1,5) was minor, but significantly increased (p<0,001) in the control group, whereby RA-patients showed a significantly higher BOP (p=0,0092). According the classification of the diagnosis, 65% of RA-patients (moderate: n=54, pronounced: n=13) and 79% of controls (moderate: n=55, pronounced: n=24) showed a periodontal disease (p=0,0234). Within the RA-group, no significant relationship was identified between the disease duration, degree of severity and activity of the RA according to the severity of the periodontal disease (p>0,05). Under bidirectional consideration, the results of this study do not show a clear relationship between rheumatoid arthritis and periodontal disease. However, it has to be considered that a majority of the RA-patients had a periodontal
dc.contributor.coRefereeOppermann, Martin Prof. Dr.
dc.subject.gerrheumatoide Arthritisde
dc.subject.engrheumatoid arthritisde
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullZahn-, Mund- und Kieferheilkunde - Allgemein- und Gesamtdarstellungen (PPN619876360)de
dc.subject.gokfullParodontologie (PPN619876409)de
dc.subject.gokfullRheumatologie (PPN619875887)de

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