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Langfristige Auswirkungen von ß-Ecdyson auf Knochen und Knorpel

Eine histomorphometrische Studie am osteoporotischen Tiermodell

dc.contributor.advisorSeidlová-Wuttke, Dana PD Dr.
dc.contributor.authorLanzer, Anne
dc.date.accessioned2014-04-17T10:58:44Z
dc.date.available2014-05-07T22:50:04Z
dc.date.issued2014-04-17
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0022-5E8C-6
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-4464
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc610de
dc.titleLangfristige Auswirkungen von ß-Ecdyson auf Knochen und Knorpelde
dc.title.alternativeEine histomorphometrische Studie am osteoporotischen Tiermodellde
dc.typedoctoralThesisde
dc.title.translatedLong-term effects of ß-ecdysone on bone and cartilagede
dc.contributor.refereeSeidlová-Wuttke, Dana PD Dr.
dc.date.examination2014-04-30
dc.description.abstractengThe major role of estrogen deficiency for pathogenesis of postmenopausal osteoporosis is well known. The phytoecdysteroid ß-ecdysone has shown bone-protective as well as bone-anabolic effects in former and mainly short-term studies. To analyze long-term effects of ß-ecdysone and evaluate its potential role in treating postmenopausal osteoporosis we used histomorphometric measurements of tibia bone and cartilage. Ovariectomized rats are a common animal model to reproduce conditions similar to those in postmenopausal osteoporosis. Following parameters were explored: thickness of joint cartilage, cortical bone, growth plate and zones, further area percentage of trabecular bone, red and yellow bone marrow as well as trabecular connectivity. Ovariectomy led to the expected serious bone loss especially in trabecular bone. There was no significant impact on cortical bone or growth plate. The administration of ß-ecdysone showed no benefit for animals that underwent ovariectomy. Only ovary-intact animals showed a significant higher trabecular bone area. In summary this study revealed only few benefits from a long-term ecdysone-application. ß-ecdysone alone seems to be unable to stop further bone loss caused by estrogen deficiency as it occurs in postmenopausal women.de
dc.contributor.coRefereeHüfner, Michael Prof. Dr.
dc.subject.gerß-Ecdysonde
dc.subject.gerpostmenopausale Osteoporosede
dc.subject.gerKnochende
dc.subject.gerKnorpelde
dc.subject.engß-ecdysonede
dc.subject.engovariectomyde
dc.subject.engpostmenopausal osteoporosisde
dc.subject.engbonede
dc.subject.engcartilagede
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0022-5E8C-6-5
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.subject.gokfullInnere Medizin - Allgemein- und Gesamtdarstellungen (PPN619875747)de
dc.subject.gokfullGynäkologie / Geburtshilfe / Perinatologie - Allgemein- und Gesamtdarstellungen (PPN619876050)de
dc.description.embargoed2014-05-07
dc.identifier.ppn783381549


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