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dc.contributor.advisor Heise, Daniel PD Dr.
dc.contributor.author Wetz, Anna Julienne
dc.date.accessioned 2014-04-17T14:22:40Z
dc.date.available 2014-04-17T14:22:40Z
dc.date.issued 2014-04-17
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-0022-5E8D-4
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc 610 de
dc.title Evaluierung, Validierung und Anwendung eines Scores zur Stratifizierung des Risikos akuter Nierenfunktionsstörungen de
dc.type doctoralThesis de
dc.title.translated Evaluation, validation and application of a predictive score for risk stratification of acute kidney injury after cardiac surgery de
dc.contributor.referee Bräuer, Anselm Prof. Dr.
dc.date.examination 2013-05-07
dc.description.abstracteng Postoperative acute kidney injury (AKI) is a frequently observed phenomenon after cardiac surgery with the use of cardio-pulmonary-bypass (CPB) and a severe complication which is associated with adverse patient outcome. To apply preventive and therapeutic measures it is essential to identify at risk patients. To estimate the individual risk for AKI, scoring systems were developed. Adequate scores then allow not only focused applying of preventive measures but also an objective analysis of its effect. This project evaluated, validated, and applied the Thakar score. Prior studies, with the endpoint criterion "renal replacement therapy", reported good discrimination but not constantly good calibration. Since implementation of RIFLE and AKIN classification, which are objective, comparable, and precise definitions of AKI, the original endpoint criterion turned obsolete. Thus, the evaluation of the consequences of applying an adequate endpoint-criterion is of predominantly clinical importance for the implementation of the Thakar score. The present study adjusted not only the endpoint-criterion to current standards but also optimized data acquisition and the evaluation of risk factors by prospective study design. However, these modifications did not lead to good calibration or discrimination. Only adding intraoperative risk factors improved discrimination. I conclude that when developing scoring systems, it is essential that they base on precise parameters, which are not in need of interpretation, and that the endpoint criterion is objective and consistent and also corresponds to current standards. This would allow correct evaluation of AKI risk and further steps of implementation and improvement of prevention and therapeutic strategies may follow. In a second part, we demonstrated the application of the Thakar score when clarifying the question if the preemptive administration of sodium bicarbonate can prevent AKI. With the use of the score we estimated and ensured comparable risk configuration in the control group and the group where patients were treated with sodium bicarbonate. I found that sodium bicarbonate significantly decreased the incidence of AKI. de
dc.contributor.coReferee Gross, Oliver Prof. Dr.
dc.subject.ger Akutes Nierenversagen de
dc.subject.ger Kardiochirurgie de
dc.subject.ger Score de
dc.subject.ger Vorhersagemodell de
dc.subject.ger Natriumbicarbonat de
dc.subject.ger Validierung de
dc.subject.eng Acute kidney injury de
dc.subject.eng cardiac surgery de
dc.subject.eng predictive score de
dc.subject.eng sodium bicarbonate de
dc.subject.eng validation de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5E8D-4-9
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull GOK-MEDIZIN de
dc.identifier.ppn 783381565

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