Charakterisierung der Skelettmuskelregeneration im Mausmodell der Einschlusskörpermyositis
Charakterization of regeneration capicity of skeletal muscle in autoimmune neurodegenerative muscle deases in a mouse model using the example of inculsion body myositis
Schellhöh, Patrick
Dissertation
Angenommen am:2014-05-27
Erschienen:2014-05-26
Betreuer:Schmidt, Jens Prof. Dr.
Gutachter:Klinge, Lars PD Dr.
Gutachter:Sereda, Michael Werner Prof. Dr.
Zum Verlinken/Zitieren:
http://hdl.handle.net/11858/00-1735-0000-0022-5ECA-9
The inclusion body myositis is the most common acquired myopathy in patients over 50 years. The pathogenesis is not well known. Besides of degenerative and inflammatory mechanisms, an alteration in the regeneration capicity came to view of scientific investigation over the last years.
This study shows the charakterization of regeneration capicity of skeletal muscle in a mouse model of inculsion body myositis using the snake venom notexine to induce a muscle damage. We could show that there is a lack of regeneration in the muscle of IBM mice using different methods (including clinical scores, grip-strenght-measurement, histology and qPCR).
Keywords: inclusion body myositis; IBM; regeneration
