Charakterisierung der Skelettmuskelregeneration im Mausmodell der Einschlusskörpermyositis

Charakterization of regeneration capicity of skeletal muscle in autoimmune neurodegenerative muscle deases in a mouse model using the example of inculsion body myositis

by Patrick Schellhöh
Doctoral thesis
Date of Examination:2014-05-27
Date of issue:2014-05-26
Advisor:Prof. Dr. Jens Schmidt
Referee:PD Dr. Lars Klinge
Referee:Prof. Dr. Michael Werner Sereda
Persistent Address: http://dx.doi.org/10.53846/goediss-4525

 

 

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Abstract

English

The inclusion body myositis is the most common acquired myopathy in patients over 50 years. The pathogenesis is not well known. Besides of degenerative and inflammatory mechanisms, an alteration in the regeneration capicity came to view of scientific investigation over the last years.  This study shows the charakterization of regeneration capicity of skeletal muscle in a mouse model of inculsion body myositis using the snake venom notexine to induce a muscle damage. We could show that there is a lack of regeneration in the muscle of IBM mice using different methods (including clinical scores, grip-strenght-measurement, histology and qPCR). 
Keywords: inclusion body myositis; IBM; regeneration
 
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