Characterization of the CNS-specific F-box protein FBXO41 in cerebellar development

Holubowska, Anna

dc.contributor.advisor	Stegmüller, Judith Dr.
dc.contributor.author	Holubowska, Anna
dc.date.accessioned	2014-05-28T08:38:51Z
dc.date.available	2014-05-28T08:38:51Z
dc.date.issued	2014-05-28
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0022-5ECB-7
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4526
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	570	de
dc.title	Characterization of the CNS-specific F-box protein FBXO41 in cerebellar development	de
dc.type	doctoralThesis	de
dc.contributor.referee	Stegmüller, Judith Dr.
dc.date.examination	2013-10-23
dc.description.abstracteng	During neurodevelopment, processes like neurogenesis, neuronal migration and morphogenesis, as well as synaptogenesis determine the shape and function of the brain. All developmental events are highly coordinated by extrinsic and intrinsic signaling pathways. The ubiquitin-proteasome system emerges as specific intrinsic regulator of brain development as well as target for therapeutic approaches. In this study, I identified the UPS component and an F-box protein FBXO41 as a CNS-specific protein expressed exclusively in neurons. I found that FBXO41 specifically stimulates axon growth in cerebellar granule neurons in vitro and in vivo. In addition, I discovered that FBXO41 is crucial for the migration of CGNs in the developing cerebellar cortex. At the molecular level, I also found that FBXO41 fs centrosomal localization is important for its role in neuronal migration but not for axon growth. In addition, I uncovered that FBXO41 associates with DISC1 to cooperate in neuronal migration but this interaction is dispensable for axon growth regulation. Taken together, my study led to the identification of the novel CNS-specific F-box protein FBXO41 and the characterization of its role in crucial aspects of cerebellar development.	de
dc.contributor.coReferee	Ehrenreich, Hannelore Prof. Dr. Dr.
dc.contributor.thirdReferee	Fischer, André Prof. Dr.
dc.contributor.thirdReferee	Stoykova, Anastassia Prof. Dr.
dc.contributor.thirdReferee	Wodarz, Andreas Prof. Dr.
dc.contributor.thirdReferee	Heinrich, Ralf Prof. Dr.
dc.subject.eng	FBXO41	de
dc.subject.eng	neurodevelopment	de
dc.subject.eng	axon growth	de
dc.subject.eng	neuronal migration	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5ECB-7-8
dc.affiliation.institute	Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)	de
dc.subject.gokfull	Biologie (PPN619462639)	de
dc.identifier.ppn	78674197X

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Das Dokument erscheint in:

GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften [1112]
GGNB - Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences

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