Osteoporose - Das Metabolische Syndrom des Knochens - Wirkungen von Ecdyson und Vitamin D auf den postmenopausalen, osteoporotischen Knochen im Zusammenhang mit dem Metabolischen Syndrom

Osteoporosis - The Metabolic Syndrome of the Bone - The effects of ecdysone and vitamin d on postmenopausal, osteoporotic bones associated with the metabolic syndrome

"Effects of ecdysone and vitamin D on the postmenopausal osteoporotic bone associated with the metabolic syndrome"

by Lucas Dannenberg
Doctoral thesis
Date of Examination:2014-01-21
Date of issue:2014-06-10
Advisor:PD Dr. Dana Seidlová-Wuttke
Referee:PD Dr. Dana Seidlová-Wuttke
Referee:PD Dr. Stephan Sehmisch
Persistent Address: http://dx.doi.org/10.53846/goediss-4542

 

 

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Abstract

English

Osteoporosis is a systemic skeletal disease, a disease that affects women, especially in the postmenopausal phase of life. At the same time postmenopausal women have an increased risk of getting the metabolic syndrome. This is a condition which enhances the development of osteoporosis. The aim of this study was to investigate the effects of ecdysone and vitamin d on postmenopausal, osteoporotic bones associated with the metabolic syndrome. For this reason the effects of ecdysone, vitamin d and estradiol should be demonstrated by feeding the substances to ovariectomized rats and using histological methods. In reference to this, body-weight, thickness of joint cartilage, cortical bone, growth plate and zones, further area percentage of trabecular bone, red and yellow bone marrow and different serum markers (cholesterol, leptin, glucose, osteocalcin, rat-laps) were determined. Ovariectomy led to the expected serious bone loss and an increase in body weight. Ecdysone has beneficial effects on body-weight, serum leptin levels and bone markers and may be able to prevent the metabolic syndrome of the bone.
Keywords: ovariectomy; postmenonpausal osteoporosis; metabolic syndrome; bone; ecdysone; vitamin d; estradiol
 
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