Osteoporose - Das Metabolische Syndrom des Knochens - Wirkungen von Ecdyson und Vitamin D auf den postmenopausalen, osteoporotischen Knochen im Zusammenhang mit dem Metabolischen Syndrom

Dannenberg, Lucas

dc.contributor.advisor	Seidlová-Wuttke, Dana PD Dr.
dc.contributor.author	Dannenberg, Lucas
dc.date.accessioned	2014-06-10T13:31:32Z
dc.date.available	2014-06-10T13:31:32Z
dc.date.issued	2014-06-10
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0022-5EE2-2
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4542
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4542
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	Osteoporose - Das Metabolische Syndrom des Knochens - Wirkungen von Ecdyson und Vitamin D auf den postmenopausalen, osteoporotischen Knochen im Zusammenhang mit dem Metabolischen Syndrom	de
dc.type	doctoralThesis	de
dc.title.translated	Osteoporosis - The Metabolic Syndrome of the Bone - The effects of ecdysone and vitamin d on postmenopausal, osteoporotic bones associated with the metabolic syndrome	de
dc.contributor.referee	Seidlová-Wuttke, Dana PD Dr.
dc.date.examination	2014-01-21
dc.description.abstracteng	Osteoporosis is a systemic skeletal disease, a disease that affects women, especially in the postmenopausal phase of life. At the same time postmenopausal women have an increased risk of getting the metabolic syndrome. This is a condition which enhances the development of osteoporosis. The aim of this study was to investigate the effects of ecdysone and vitamin d on postmenopausal, osteoporotic bones associated with the metabolic syndrome. For this reason the effects of ecdysone, vitamin d and estradiol should be demonstrated by feeding the substances to ovariectomized rats and using histological methods. In reference to this, body-weight, thickness of joint cartilage, cortical bone, growth plate and zones, further area percentage of trabecular bone, red and yellow bone marrow and different serum markers (cholesterol, leptin, glucose, osteocalcin, rat-laps) were determined. Ovariectomy led to the expected serious bone loss and an increase in body weight. Ecdysone has beneficial effects on body-weight, serum leptin levels and bone markers and may be able to prevent the metabolic syndrome of the bone.	de
dc.contributor.coReferee	Sehmisch, Stephan PD Dr.
dc.title.alternativeTranslated	"Effects of ecdysone and vitamin D on the postmenopausal osteoporotic bone associated with the metabolic syndrome"	de
dc.subject.eng	ovariectomy	de
dc.subject.eng	postmenonpausal osteoporosis	de
dc.subject.eng	metabolic syndrome	de
dc.subject.eng	bone	de
dc.subject.eng	ecdysone	de
dc.subject.eng	vitamin d	de
dc.subject.eng	estradiol	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5EE2-2-7
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Endokrinologie (PPN619875836)	de
dc.identifier.ppn	788243667

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