Connexine als potenzielle Biomarker für den Progress oraler Plattenepithelkarzinome: Analyse der Expressionsmuster von Connexin 26, 43 und 45 und ihres Einflusses auf das Überleben

Brockmeyer, Phillipp

dc.contributor.advisor	Hemmerlein, Bernhard PD Dr.
dc.contributor.author	Brockmeyer, Phillipp
dc.date.accessioned	2014-06-16T11:54:27Z
dc.date.available	2014-07-09T22:50:06Z
dc.date.issued	2014-06-16
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0022-5EE8-5
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4545
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	Connexine als potenzielle Biomarker für den Progress oraler Plattenepithelkarzinome: Analyse der Expressionsmuster von Connexin 26, 43 und 45 und ihres Einflusses auf das Überleben	de
dc.type	doctoralThesis	de
dc.title.translated	Connexins as potential biomarkers for the progression of oral squamous cell carcinoma: analysis of the expression pattern of connexin 26, 43 and 45 and their influence on survival	de
dc.contributor.referee	Hemmerlein, Bernhard PD Dr.
dc.date.examination	2014-07-02
dc.description.abstracteng	The aim of the present study was to evaluate the expression and localization of connexin (Cx) 26, -43 and -45 in a group of 35 patients with primary oral squamous cell carcinoma (OSCC) with the objective of making a more accurate disease prognosis. We analysed the expression of connexins in tissue samples of primary OSCC, matching oral mucosa free of dysplasia, and it’s associated lymph node metastases (LNM) by semiquantitative immunohistochemistry of membrane, cytoplasmic and nuclear connexin expression. The level of expression was correlated with the overall survival time (OS). Cx43 was overexpressed in tumour cells compared to epithelia in dysplasia-free mucosa. High membrane expression of Cx43 on tumour cells was the only statistically significant and independent prognostic factor of short OS (p=0.0088). Membrane expression of Cx43 in matching dysplasia-free mucosa acted similarly, but did not reach statistical significance (p=0.059). No correlation was found between the Cx26, Cx45 expression and OS. We conclude that Cx43 expression in dysplasia-free mucosa may indicate a very early stage of tumour promotion. Although overexpression of Cx43 is found in invasive tumours we only found membrane Cx43 expression to correlate with OS. This observation suggests that cytoplasmic Cx43 serves as storage and only membrane translocation may promote the formation of gap junctions and gap junctional intercellular communication (GJIC) with prognostic relevance.	de
dc.contributor.coReferee	Rödel, Ralph Prof. Dr.
dc.subject.eng	gap junctional intercellular communication	de
dc.subject.eng	oral squamous cell carcinoma	de
dc.subject.eng	connexin 26	de
dc.subject.eng	connexin 43	de
dc.subject.eng	connexin 45	de
dc.subject.eng	prognosis	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5EE8-5-6
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Pathologie / Pathologische Anatomie / Histopathologie / Zytopathologie - Allgemein- und Gesamtdarstellungen (PPN619875674)	de
dc.identifier.ppn	788243845

Files in this item

Name:Brockmeyer.pdf

Size:2.861Mb

Format:PDF

View/Open

Name:: Brockmeyer.pdf
Size:: 2.861Mb
Format:: PDF

View/Open

This item appears in the following Collection(s)

Human- und Zahnmedizin [2873]

Show simple item record