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Einsatz von Vibrationstraining als supportive Maßnahme begleitend zu allogenen hämatopoetischen Stammzelltransplantationen. Pilotstudie zu Sicherheit, Machbarkeit und Effektivität

dc.contributor.advisorTrümper, Lorenz Prof. Dr.
dc.contributor.authorTroendlin, Florian
dc.date.accessioned2014-06-24T08:38:52Z
dc.date.available2014-07-16T22:50:05Z
dc.date.issued2014-06-24
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0022-5EF4-9
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-4558
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc610de
dc.titleEinsatz von Vibrationstraining als supportive Maßnahme begleitend zu allogenen hämatopoetischen Stammzelltransplantationen. Pilotstudie zu Sicherheit, Machbarkeit und Effektivitätde
dc.typedoctoralThesisde
dc.title.translatedUse of vibration training as a supportive measure concomitantly allogeneic hematopoietic stem cell transplantation. Pilot study on safety, feasibility and effectivenessde
dc.contributor.refereeNiklas, André Prof. Dr.
dc.date.examination2014-07-09
dc.description.abstractengIn this prospective, randomized pilot study the feasibility, safety and effectiveness of vibration training (every 2 days) for patients, who undergo an allogeneic hematopoietic stem cell transplantation (allo-HSCT) during this training, was investigated. In the present thesis 26 patients were divided randomly into 2 groups: a vibration intervention group receiving conventional physiotherapy and additional vibration training and a control group only receiving conventional physiotherapy. Between these two groups the influence of the treatment on muscle strength, functional performance, QOL and clinical outcome was compared. . This pilot study showed that vibration training in compliance with the exclusion criteria in the context of allo-HSCT is safe, feasible and effective with a training participation of 83%. Despite significantly more frequent general physiotherapy in the control group (p = 0.005), the study showed a trend that vibration training had a greater influence on strengthen the leg strength (comparison of "hospitalization" with "release": eg control -15%, intervention +6.9% at 180 ° / s extension, p = 0, 07) in the isokinetic testing of the dominant leg extension and flexion as well as on muscular endurance. Increased endurance performance in the Six-Minute Walk Test compared with the control group was not achieved. In the EORTC QLQ C-30, a significant loss of quality of life (p = 0.04) and physical function (p = 0.02) was shown in the total cohort. However, a trend towards less burden of pain could be shown for the intervention group (p = 0.05).de
dc.contributor.coRefereeSchön, Margarete Prof. Dr.
dc.subject.gerVibrationstrainingde
dc.subject.gerallogene hämatopoetische Stammzelltransplantationde
dc.subject.gerLebensqualitätde
dc.subject.engvibration trainingde
dc.subject.engallogeneic SCTde
dc.subject.engexercisede
dc.subject.engquality of lifede
dc.subject.engphysical and functional capacityde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0022-5EF4-9-9
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.description.embargoed2014-07-16
dc.identifier.ppn788716298


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