| dc.contributor.advisor | Weiser, Hans-Fred Prof. Dr. | |
| dc.contributor.author | Crnogorac, Vladan | |
| dc.date.accessioned | 2014-07-11T08:45:46Z | |
| dc.date.available | 2014-07-23T22:50:05Z | |
| dc.date.issued | 2014-07-11 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0022-5F11-1 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-4596 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Anastomosenprotektion am Kolorektum durch Umhüllung mit Small intestinal submucosa im Großtiermodell des Schweins | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | Small intestinal submucosa for reinforcement of colonic anastomosis | de |
| dc.contributor.referee | Schwörer, Harald Prof. Dr. | |
| dc.date.examination | 2014-07-16 | |
| dc.description.abstracteng | Background Different materials have been evaluated for
anastomotic reinforcement to prevent gastrointestinal anastomotic
leakage. In this experimental study, small intestinal
submucosa (SIS) was tested as a sealing for stapled colonic
anastomosis in a porcine model. The aims of this study
were to determine the macroscopic and microscopic outcomes
and to evaluate the safety and feasibility of applying
SIS for anastomotic sealing.
Materials and methods Circular stapled anastomoses were
performed in 18 pigs. Standard anastomosis in the control
group (n=8) was compared to an SIS-sealed anastomosis in
the study group (n=10). After 30 days, anastomotic
segments were examined for macroscopic and microscopic
regeneration and their resistance to mechanical stress.
Furthermore, animal survival and clinical course were
evaluated.
Results None of the animals developed anastomotic leakage,
intraabdominal abscess, or peritonitis. Shrinkage of
SIS was evident in nine of ten animals. Encapsulation and
displacement of the SIS patches were seen in two animals.
Quantity of anastomotic granulation tissue and rate of
complete mucosal coverage of anastomotic line were
increased in SIS-sealed anastomoses without reaching
significance. Moreover, no significant differences were
found in the rate of survival of the animals, anastomotic
stricture formation, intraabdominal adhesions, anastomotic
bursting pressure, and microscopic healing parameters of
the anastomosis between stapled colonic standard anastomosis
and anastomosis protected by SIS.
Conclusion The results of this study indicate a safe use of
SIS for anastomotic reinforcement in a porcine model.
Adverse effects like strictures, increased adhesions, and
anastomotic abscesses were absent. Promoting effects on
colonic wound healing by SIS were microscopically
evident. The results argue for a careful clinical evaluation
in humans. | de |
| dc.contributor.coReferee | Schön, Margarete Prof. Dr. | |
| dc.subject.ger | Small intestinal submucosa . Anastomosen . Kolon . Protektion | de |
| dc.subject.eng | Small intestinal submucosa . Anastomosis . Colon . Reinforcement | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5F11-1-2 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Chirurgie - Allgemein- und Gesamtdarstellungen (PPN619875968) | de |
| dc.description.embargoed | 2014-07-23 | |
| dc.identifier.ppn | 790375273 | |