dc.contributor.advisor | Quintel, Michael Prof. Dr. | |
dc.contributor.author | Weigel, Cathrin | |
dc.date.accessioned | 2014-07-28T08:45:31Z | |
dc.date.available | 2014-09-08T22:50:06Z | |
dc.date.issued | 2014-07-28 | |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0022-5F34-4 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-4613 | |
dc.language.iso | deu | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Quantifizierung von Sevofluran an Anästhesiearbeitsplätzen mittels Ionenmobilitätsspektrometrie | de |
dc.type | doctoralThesis | de |
dc.title.translated | Quantification of occupational exposure to sevoflurane in anaesthesia workplaces using multi- capillary column- ion mobility spectrometry (MCC- IMS) | de |
dc.contributor.referee | Heutelbeck, Astrid PD Dr. | |
dc.date.examination | 2014-08-11 | |
dc.description.abstracteng | Background: Occupational exposure to sevoflurane has the potential to cause health
damage in hospital personnel. Workplace contamination with the substance is mostly
assessed using photoacoustic infrared spectrometry or flame ionization detector.
Multi-capillary column-ion mobility spectrometry (MCC-IMS) could be an alternative
technology for the quantification of sevoflurane in the room air and even be more
accurate because of potentially lower detection limits. In principal other volatile
anaesthetics could be detected and quantified simultaneously by using MCC-IMS.
Objective: To test the hypothesis that MCC-IMS is able to detect and monitor very low
concentrations of sevoflurane in a hospital setting. To evaluate the
exposure of hospital personnel to sevoflurane during paediatric anaesthesia and in the
post anaesthesia care unit (PACU).
Design: Observational study.
Setting: University Medical Centre of Göttingen in Germany: Paediatric dental surgical
theatre (from June 19th 2012 until August 7th 2012); PACU (from October 27th 2009
until October 29th 2009).
Main outcome measures: The limits of detection (LOD) and quantification (LOQ) of the
MCC-IMS for sevoflurane and the sevoflurane exposure of hospital personnel
measured by MCC-IMS and calculated as time-weighted average (TWA) values.
Results: The LOD was 0.0068 ppbv and the LOQ was 0.0189 ppbv. During paediatric
anaesthesia the mean sevoflurane concentration was 0,4602ppmv (0,0754 – 3,1473ppmv) with
TWA values between 0,0052 and 0,0365ppmv. In the PACU the mean sevoflurane
concentration was 0,0279ppmv (0,008 – 0,1702ppmv) and TWA values reached from 0,0093 to
0,0967ppmv.
Conclusion: The detection and the quantification of sevoflurane by the use of MCC-IMS is possible.
It is a reliable technology for monitoring sevoflurane concentrations at
anaesthesia workplaces and has a particular strength in quantifying low-level
contaminations of sevoflurane. The exposure of the personnel working in these areas
did not exceed recommended limits and therefore adverse health effects are unlikely. | de |
dc.contributor.coReferee | Mausberg, Rainer Prof. Dr. | |
dc.subject.ger | Sevofluran | de |
dc.subject.ger | Ionenmobilitätsspektrometrie | de |
dc.subject.eng | Sevoflurane | de |
dc.subject.eng | Multi capillary column ion mobility spectrometry | de |
dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5F34-4-2 | |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Medizin (PPN619874732) | de |
dc.subject.gokfull | Anästhesiologie / Intensivmedizin / Notfallmedizin / Analgesie - Allgemein- und Gesamtdarstellungen (PPN619875917) | de |
dc.description.embargoed | 2014-08-18 | |
dc.identifier.ppn | 791336379 | |