Searching for molecular mechanisms of psychiatric diseases: examples from autism to rapid cycling

by Artem Gurvich
Doctoral thesis
Date of Examination:2014-07-29
Date of issue:2014-07-31
Advisor:Prof. Dr. Dr. Hannelore Ehrenreich
Referee:Prof. Dr. André Fischer
Referee:Prof. Dr. Nils Brose
Persistent Address: http://dx.doi.org/10.53846/goediss-4634

 

 

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Abstract

English

The thesis describes several projects exploring the molecular mechanisms of psychiatric disorders. First project studies the contribution of common variants of autism related synaptic genes to neuropsychiatric risk, as exemplified in schizophrenia. Another project studies D. melanogaster, lacking dnrxn1 and dnlgn2, as a plausible model for autism spectrum disorders. Third project explores the role of prostaglandins in the rapid cycling bipolar disorder.
Keywords: autism, schizophrenia, rapid cycling, bipolar disorder, prostaglandins, celicoxib, neurexin, neuroligin, PTGDS, drosophila melanogaster
 
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