Vergleichende lichtmikroskopische Untersuchung von gesundem und erkranktem parodontalem Ligament (PDL) des Menschen

Schories, Hauke

dc.contributor.advisor	Miosge, Nicolai Prof. Dr.
dc.contributor.author	Schories, Hauke
dc.date.accessioned	2014-08-29T09:21:02Z
dc.date.available	2014-09-23T22:50:05Z
dc.date.issued	2014-08-29
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0022-5F5F-6
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4650
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	Vergleichende lichtmikroskopische Untersuchung von gesundem und erkranktem parodontalem Ligament (PDL) des Menschen	de
dc.type	doctoralThesis	de
dc.title.translated	Light microscopic study of human periodontal ligament (PDL) by comparing healthy and disseased tissue	de
dc.contributor.referee	Wiegand, Anette Prof. Dr.
dc.date.examination	2014-09-16
dc.description.abstracteng	Inflammatory disease of the periodontium (periodontitis) is characterised by an irreversible loss of tissue that anchored the teeth. In Germany periodontitis has replaced caries as the main reason for the loss of teeth. The present study is focused on the periodontal ligament (PDL) that finally enables the connection to the alveolar bone. As a functional unit the periodontium includes - beside gingiva, cementum and PDL - also the alveolar bone. That is the reason why experimental research on humans is ethically hindered and the main evidence is won by animal research. Nevertheless there are some important histological studies about the human PDL that especially investigate cellulary, structural and extracellular matrix elements, also concerning stem cells. However lots of questions about human PDL could not be answered yet. According to the present state of knowledge a systematic study of human periodontal ligament by comparing healthy and disseased tissue does not exist. So it is the aim of the present paper to win more evidence in research of the human PDL. By using the inflammatory markers HAM-56, CD 11b and anti-neutrophil-elastase the present study showed that principally there are more infammatory cells in the disseased PDL, but actually their quantity was quite less. The characterisation of fibroblasts and cells closed to the cementum showed a higher amount and bigger size of cells in the healthy PDL that is probably caused by aging process. The immunohistochemical detection of coallagen type I, III, IV and XII does not show any difference between heathy and disseased samples. Nonetheless – in contrast to earlier investigations – collagen type III could not be detected in the cementum. According to the present stage of knowledge the verification of collagen type XII in the human PDL was provided for the first time. Apart from the presence of a tendentially higher amout of CD 90-positive endothelial cells, the investigation of the human PDL - by using the adhesion molecules CD 29, 44 and 90 - showed no disparity between heathy and disseased tissue. Still, according to the present state of knowledge, in the present study the detection of CD 29- and CD 90-positive fibroblasts and cells closed to the cementum, as well as CD 29-, CD 44- and CD 90-positive endothelial cells were provided in healthy and disseased human PDL for the first time.	de
dc.contributor.coReferee	Oppermann, Martin Prof. Dr.
dc.subject.ger	PDL	de
dc.subject.ger	parodontales Ligament	de
dc.subject.ger	Lichrmikroskopie	de
dc.subject.ger	gesund	de
dc.subject.ger	erkrankt	de
dc.subject.ger	Parodontitis	de
dc.subject.ger	Kollagen	de
dc.subject.eng	PDL	de
dc.subject.eng	periodontal ligament	de
dc.subject.eng	periodontitis	de
dc.subject.eng	healthy	de
dc.subject.eng	diseased	de
dc.subject.eng	light microscopy	de
dc.subject.eng	collagen	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5F5F-6-1
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Zahn-, Mund- und Kieferheilkunde - Allgemein- und Gesamtdarstellungen (PPN619876360)	de
dc.description.embargoed	2014-09-23
dc.identifier.ppn	796514755

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