Vergleichende Untersuchung der Effekte schwacher transkranieller Gleichstromstimulation in Abhängigkeit von der Händigkeit der Probanden

Schade, Sebastian

dc.contributor.advisor	Antal, Andrea Prof. Dr.
dc.contributor.author	Schade, Sebastian
dc.date.accessioned	2014-09-05T08:57:17Z
dc.date.available	2014-10-07T22:50:05Z
dc.date.issued	2014-09-05
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0022-5F69-C
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4668
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	Vergleichende Untersuchung der Effekte schwacher transkranieller Gleichstromstimulation in Abhängigkeit von der Händigkeit der Probanden	de
dc.type	doctoralThesis	de
dc.title.translated	Comparing modulating effects of transcranial direct current stimulation due to subjects' handedness	de
dc.contributor.referee	Manzke, Till PD Dr. Dr.
dc.date.examination	2014-09-30
dc.description.abstracteng	Transcranial direct current stimulation (tDCS) has proven to be a useful tool for fundamental brain research as well as for attempts in therapy of neurological and psychiatric diseases by modulating neuronal plasticity. Little is understood how the effects of tDCS are influenced by hemispheric dominance, even less in terms of handedness. The aim of this study was to investigate whether tDCS induced neuroplastic changes may be different in right- and left-handed individuals due to existing differences in hemispheric lateralisation. We measured changes in motor evoked potentials (MEPs) after application of tDCS in 8 right-handers, 8 left-handers and 8 mixed-handers according to the Edinburgh Handedness Inventory (EHI). In double-blind sessions, we applied either anodal or cathodal tDCS for 5 minutes for each hemisphere. While motor thresholds (MT) seem to be not influenced by handedness significantly, in right-handed subjects we reproduced the well-known effects of tDCS: anodal stimulation increased while cathodal stimulation decreased MEP amplitudes. However, left-and mixed-handed subjects differed from right-handed subjects. After anodal stimulation of the left hemisphere the increase of the MEP amplitudes was stronger in right handed subjects than in left and mixed handed subjects. Interestingly, after cathodal stimulation of the left hemisphere this difference was less marked. The stimulation of the right hemisphere showed the same tendency, but results were not significant. For the first time, we are able to demonstrate that the modulating effects of tDCS on corticospinal excitability differ moderately in the left-and mixed-handed population compared to right-handed subjects. The shown differences according to handedness should be taken into account in further studies.	de
dc.contributor.coReferee	Oppermann, Martin Prof. Dr.
dc.subject.ger	hemisphärische Asymmetrie	de
dc.subject.ger	Händigkeit	de
dc.subject.ger	Edinburgh Handedness Inventory (EHI)	de
dc.subject.ger	motorisch evozierte Potentiale	de
dc.subject.ger	transkranielle Gleichstromstimulation	de
dc.subject.eng	Hemispheric asymmetry	de
dc.subject.eng	handedness	de
dc.subject.eng	Edinburgh Handedness Inventory (EHI)	de
dc.subject.eng	motor thresholds (MTs)	de
dc.subject.eng	motor evoked potentials (MEPs)	de
dc.subject.eng	transcranial direct current stimulation (tDCS)	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5F69-C-0
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247)	de
dc.description.embargoed	2014-10-07
dc.identifier.ppn	796514917

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Human- und Zahnmedizin [2872]

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