Show simple item record

Placebokontrollierte, doppelblinde Crossover-Studie zur Untersuchung der Wirkung einer parenteralen Gabe von Pantoprazol auf die Kontraktilität des Herzen

dc.contributor.advisorSchillinger, Wolfgang Prof. Dr.
dc.contributor.authorHein , Nina Celine
dc.titlePlacebokontrollierte, doppelblinde Crossover-Studie zur Untersuchung der Wirkung einer parenteralen Gabe von Pantoprazol auf die Kontraktilität des Herzende
dc.title.translatedA double-blind, placebo-controlled cross-over trial of pantoprazole and it´s effects on myocardial contractionde
dc.contributor.refereeSchillinger, Wolfgang Prof. Dr.
dc.description.abstractengPurpose: Reports on cardiac problems with oral proton pump inhibitors have caused extensive safety reviews by the US Food and Drug Administration. We provide addi- tional data on acute cardiac effects of an intravenous application. Methods: Echocardiography was performed in 18 healthy volunteers after administration of a common high-dose regimen of pantoprazole (80 mg i.v. bolus followed by 8 mg/h for 1 h) or placebo. Design: The design included a randomized, double-blind, placebo-controlled cross-over trial. Results: Ejection fraction (%, mean ± SE) in the treat- ment group (placebo group) was 60.7 ± 1.1 (61.2 ± 1.7) at baseline, and 62.6 ± 1.1 (62.1 ± 1.9), 64.7 ± 1.6 (63.5 ± 1.3), 62.6 ± 1.6 (61.0 ± 1.6) and 63.0 ± 1.4 (61.8 ± 1.5) at 7.5, 15, 30 and 60 min after bolus appli- cation, respectively (p = n.s.). Similarly, no significant changes were found for cardiac output, cardiac index, blood pressure and heart rate. In contrast, gastric pH that was used as a treatment control was significantly increased 60 min after the application of pantoprazole as compared to baseline and to placebo. Conclusions: Pantoprazole as injection is safe in healthy subjects with respect to cardiac contractile function. However, in view of recent reports of negative inotropy of the drug, further studies in heart failure patients are
dc.contributor.coRefereeTzvetkov, Mladen Dr.
dc.subject.engCardiac outputde
dc.subject.engHeart failurede
dc.subject.engCardiotonic agentsde
dc.subject.engMyocardial contractionde
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullInnere Medizin - Allgemein- und Gesamtdarstellungen (PPN619875747)de
dc.subject.gokfullPharmakologie / Toxikologie / Pharmakotherapie - Allgemein- und Gesamtdarstellungen (PPN61987550X)de

Files in this item


This item appears in the following Collection(s)

Show simple item record