Experimentelle Untersuchung zur Alveolarkammaugmentation mit Trikalziumphosphat-Hydroxylapatit-Komposit eingebettet in eine Poloxamermatrix

Experimental investigation of a self-curing resorbable polymer combined with tricalciumphosphate/hydroxylapatite grafting material in vertical ridge augmentations

by Mona Köwing
Doctoral thesis
Date of Examination:2015-03-16
Date of issue:2015-03-23
Advisor:Prof. Dr. Dr. Henning Schliephake
Referee:Prof. Dr. Dr. Henning Schliephake
Referee:Prof. Dr. Nicolai Miosge
Persistent Address: http://dx.doi.org/10.53846/goediss-4958

 

 

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Abstract

English

The aim of this study was to evaluate bone formation in vertical ridge augmentations using a particulate bone grafting material, which was stabilized by a resorbable polymer. In a randomized split-mouth design three critical size saddle-type defects were created in the maxillary alveolar ridge of six Beagle dogs, three month after the removal of all premolars. One defect in each dog was augmented with tricalciumphosphate/hydroxylapatite grafting material, stabilized by a Poloxamer hydrogel. For comparison one defect in each dog was filled with grafting material only and covered with a collagen membrane. Unfilled defects served as empty controls. After 14 weeks of healing, bone formation was evaluated using computer-assisted histomorphometry on undecalcified thick-section specimens. Results: No difference could be found between the amount of new bone formation, percentage of bone fill and bone density between the test group and the controls.  The only parameter that was significantly higher in the test group compared to the empty control defects was the mean maximum bone height within the augmentated area. The use of a Poloxamer gel did not result in a better preservation of the alveolar ridge shape compared to the group of augmentations covered with a collagen membrane. Thus it appears, that the use of a poloxamer gel for the stabilization of a particulate bone grafting material had no advantage compared to the use of a collagen membrane.
Keywords: bone grafting; resorbable polymer; vertical ridge augmentation; poloxamer
 
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