| dc.contributor.advisor | Gruber, Rudolf PD Dr. Dr. | |
| dc.contributor.author | Krohn, Sebastian | |
| dc.date.accessioned | 2015-04-09T09:24:03Z | |
| dc.date.available | 2015-05-05T22:50:05Z | |
| dc.date.issued | 2015-04-09 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0022-5FA6-2 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5017 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Die Rekonstruktion des Unterkiefers bei Knochendefekten mit einer Kombination aus rhBMP-2, einer synthetischen Polyethylenglycol-Matrix und Calciumphosphat -Eine Pilotstudie am Göttinger Minipig | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | The reconstruction of mandibular bone defects using a combination of rhBMP -2, a synthetic polyethylene glycol hydrogel and calcium phosphate -A pilot study in Göttingen minipigs | de |
| dc.contributor.referee | Gruber, Rudolf PD Dr. Dr. | |
| dc.date.examination | 2015-04-28 | |
| dc.description.abstracteng | Aim: To test the hypothesis that a synthetic hydroxyapatite/beta-tricalcium
phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel
including recombinant human bone morphogenetic proteins-2 (rhBMP-2)
enhances new bone formation compared with bone morphogenetic proteins-2
(BMP-2) delivered using the HA/TCP construct alone.
Material and Methods: Bilateral mandibular partial thickness 20 x 8 x 8 mm
(L x W x H) alveolar defects were surgically created in the edentulated posterior
mandible in 18 female minipigs. Randomized into two groups of nine animals
each, the alveolar defects either received HA/TCP or HA/TCP/PEG with or
without BMP-2 (105 μg/defect) in contra-lateral sites using a split-mouth design.
Primary outcome, bone density (%) within four regions of interest, was evaluated
following a 4-week healing interval when the animals were killed for histomorphometric
analysis.
Results: Bone morphogenetic proteins-2 loaded onto HA/TCP constructs significantly
enhanced new bone formation compared with HA/TCP controls. Adding
PEG apparently obstructed BMP-2 induced bone formation.
Conclusion: Polyethylene glycol compromises the osteogenic effect of BMP-2. | de |
| dc.contributor.coReferee | Gersdorff, Nikolaus Prof. Dr. | |
| dc.subject.eng | bone morphogenetic protein 2 | de |
| dc.subject.eng | jawbone defects | de |
| dc.subject.eng | maxillomandibular reconstruction | de |
| dc.subject.eng | polyethylene glycol hydrogel | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5FA6-2-3 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Medizin (PPN619874732) | de |
| dc.description.embargoed | 2015-05-05 | |
| dc.identifier.ppn | 821890999 | |