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Rolle der d-COP-Untereinheit im frühen sekretorischen Pfad

dc.contributor.advisorSchwappach, Blanche Prof. Dr.
dc.contributor.authorRichter, Kora Pauline
dc.date.accessioned2015-06-05T07:11:47Z
dc.date.available2016-12-30T23:50:11Z
dc.date.issued2015-06-05
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0022-600D-7
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-5115
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc610de
dc.titleRolle der d-COP-Untereinheit im frühen sekretorischen Pfadde
dc.typedoctoralThesisde
dc.title.translatedRole of the d-COP-subunit in the early secretory pathwayde
dc.contributor.refereeThoms, Sven PD Dr.
dc.date.examination2015-06-16
dc.description.abstractengIntracellular communication is mediated by different pathways and signals. The ER and Golgi apparatus are communicationally connected via the COP I and II vesicles. Hereby COP I is responsible for retrograde transport from Golgi to ER. A closer look at the COP I vesicle structure releaves a heteromeric heptamer. The d-COP-subunit seems to be important for the retrieval of luminal proteins back to the ER through the KDEL receptor. In this project a strain is created to analyse the function of d-COP through a complementational assay with a human gen in yeast. The findings include the relevant part of d-COP responsible for protein retrieval and bring us one step closer to understanding the pathology of diseases.de
dc.contributor.coRefereeOppermann, Martin Prof. Dr.
dc.subject.gerKDEL-Rezeptorde
dc.subject.gerERde
dc.subject.gerGolgide
dc.subject.gerCOPIde
dc.subject.gerVesikeltransportde
dc.subject.engKDEL-receptorde
dc.subject.engCOPIde
dc.subject.engvesicle transportde
dc.subject.engEndoplasmatic Reticulumde
dc.subject.engGolgide
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0022-600D-7-4
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullBiochemie / Physiologische Chemie / Pathobiochemie - Allgemein- und Gesamtdarstellungen (PPN619875313)de
dc.description.embargoed2016-12-30
dc.identifier.ppn826792103


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