dc.contributor.advisor | Schwappach, Blanche Prof. Dr. | |
dc.contributor.author | Richter, Kora Pauline | |
dc.date.accessioned | 2015-06-05T07:11:47Z | |
dc.date.available | 2016-12-30T23:50:11Z | |
dc.date.issued | 2015-06-05 | |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0022-600D-7 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5115 | |
dc.language.iso | deu | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Rolle der d-COP-Untereinheit im frühen sekretorischen Pfad | de |
dc.type | doctoralThesis | de |
dc.title.translated | Role of the d-COP-subunit in the early secretory pathway | de |
dc.contributor.referee | Thoms, Sven PD Dr. | |
dc.date.examination | 2015-06-16 | |
dc.description.abstracteng | Intracellular communication is mediated by different pathways and signals. The ER and Golgi apparatus are communicationally connected via the COP I and II vesicles. Hereby COP I is responsible for retrograde transport from Golgi to ER. A closer look at the COP I vesicle structure releaves a heteromeric heptamer. The d-COP-subunit seems to be important for the retrieval of luminal proteins back to the ER through the KDEL receptor. In this project a strain is created to analyse the function of d-COP through a complementational assay with a human gen in yeast. The findings include the relevant part of d-COP responsible for protein retrieval and bring us one step closer to understanding the pathology of diseases. | de |
dc.contributor.coReferee | Oppermann, Martin Prof. Dr. | |
dc.subject.ger | KDEL-Rezeptor | de |
dc.subject.ger | ER | de |
dc.subject.ger | Golgi | de |
dc.subject.ger | COPI | de |
dc.subject.ger | Vesikeltransport | de |
dc.subject.eng | KDEL-receptor | de |
dc.subject.eng | COPI | de |
dc.subject.eng | vesicle transport | de |
dc.subject.eng | Endoplasmatic Reticulum | de |
dc.subject.eng | Golgi | de |
dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0022-600D-7-4 | |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Biochemie / Physiologische Chemie / Pathobiochemie - Allgemein- und Gesamtdarstellungen (PPN619875313) | de |
dc.description.embargoed | 2016-12-30 | |
dc.identifier.ppn | 826792103 | |