Bedeutung einer Beeinträchtigung der D2- und D3-vermittelten dopaminergen Transmission für die motorische Aktivität und das motorische Lernverhalten im Mausmodell

Hasan, Kenan

dc.contributor.advisor	Klinker, Florian Dr.
dc.contributor.author	Hasan, Kenan
dc.date.accessioned	2015-06-29T08:18:59Z
dc.date.available	2015-07-06T22:50:06Z
dc.date.issued	2015-06-29
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0022-603C-E
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5128
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5128
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Bedeutung einer Beeinträchtigung der D2- und D3-vermittelten dopaminergen Transmission für die motorische Aktivität und das motorische Lernverhalten im Mausmodell	de
dc.type	doctoralThesis	de
dc.title.translated	The significance of an impairment of the D2-/D3-mediated dopaminergic transmission for motor activity and motor learning in mice	de
dc.contributor.referee	Liebetanz, David Prof. Dr.
dc.date.examination	2015-06-29
dc.description.abstracteng	We investigated the locomotor activity and motor learning in running wheel experiments in mice under influence of the dopaminergic system. We evaluated an impairment of the D2 function by using knockout mice and after pharmacological Blockade of the D2 receptor and a lack of D3 function by using D3 knockout mice with and without influence of the dopaminergic system by dietary-induced iron deficiency. A reduction of the D2 receptor function in the D2 knockout mouse or after injection of D2 receptor antagonist raclopride resulted in a significant limitation of all parameters in the normal running wheel. The reduced activity was mainly evident in the quantity of Runs, and much less in a reduced maximum speed, which argues against a purely motor deficit like in Parkinsonoid-diseases. Since the use of the running-wheel (in contrast to habitual movement) requires a high level of motivation, the impairment of the D2 system at the interface between motivation and motor skills leading to a reduced drive to motor activity is a traceable explanation. In the second experiment, we examined the effects of iron deficiency and a lack of the D3 receptor on motor activity and motor learning. An iron-restricted diet led in D3 Knockout mice as well as in wild-type controls to a reduction in the total distance with an unaltered maximum speed. According to previous studies an anemia-induced effect is unlikely to explain theses results. The combination of iron deficiency and lack of D3 receptor resulted in a delay of learning of the new pattern in the complex running wheel, while the single deficiencies did not affect the learning performance. Thus, although activation of the D3 receptor inhibits the learning process in healthy mice, a lack of D3 receptor in coexisting iron deficiency causes additional learning deficits.	de
dc.contributor.coReferee	Fischer, André Prof. Dr.
dc.contributor.thirdReferee	Mausberg, Rainer Prof. Dr.
dc.subject.ger	Dopamin	de
dc.subject.ger	Motorisches Lernen	de
dc.subject.ger	D2-Rezeptor	de
dc.subject.ger	D3-Rezeptor	de
dc.subject.ger	Laufrad	de
dc.subject.eng	motor learning	de
dc.subject.eng	dopamine	de
dc.subject.eng	d2 receptor	de
dc.subject.eng	d3 receptor	de
dc.subject.eng	running wheel	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0022-603C-E-9
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Physiologie / Pathophysiologie - Allgemein- und Gesamtdarstellungen (PPN619875283)	de
dc.subject.gokfull	Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247)	de
dc.description.embargoed	2015-07-06
dc.identifier.ppn	828597529

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Human- und Zahnmedizin [2872]

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