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Synthesis of fluorescent toxin and nucleotide derivatives to specifically address membrane proteins

dc.contributor.advisorDiederichsen, Ulf Prof. Dr.
dc.contributor.authorRadzey, Hanna Agnes
dc.date.accessioned2015-07-15T09:02:48Z
dc.date.available2015-07-15T09:02:48Z
dc.date.issued2015-07-15
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0022-6055-5
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-5177
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-5177
dc.language.isoengde
dc.publisherNiedersächsische Staats- und Universitätsbibliothek Göttingende
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc540de
dc.titleSynthesis of fluorescent toxin and nucleotide derivatives to specifically address membrane proteinsde
dc.typedoctoralThesisde
dc.contributor.refereeDiederichsen, Ulf Prof. Dr.
dc.date.examination2015-04-01
dc.description.abstractengWithin this project, new tools for in vivo/in vitro labelling were developed and investigated, which may be utilized in the future to elucidate structures, localisation and distinct processes of biomolecules in their native environment. Fluorescence labelling and detection provides researchers with a highly sensitive, non-destructive method to visualize biomolecules even on the nanometre scale. This thesis comprises two different approaches for fluorescent labelling. The first approach includes the indirect labelling of ion channels, in which ion channels are addressed by specific binding fluorescently labelled neurotoxins. The second project involves a direct labelling approach, where a nucleotide is functionalized with a fluorophore for direct investigation of its concentration and localisation.de
dc.contributor.coRefereeJanshoff, Andreas Prof. Dr.
dc.contributor.thirdRefereeAckermann, Lutz Prof. Dr.
dc.contributor.thirdRefereeKoszinowski, Konrad Prof. Dr.
dc.contributor.thirdRefereeHöbartner, Claudia Prof. Dr.
dc.contributor.thirdRefereeSiewert, Inke Dr.
dc.subject.engfluorescent labellingde
dc.subject.engconotoxinde
dc.subject.engpompilidotoxinde
dc.subject.engiberiotoxinde
dc.subject.engcAMPde
dc.subject.engdisulphide rich peptidesde
dc.subject.engcagingde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0022-6055-5-0
dc.affiliation.instituteFakultät für Chemiede
dc.subject.gokfullChemie  (PPN62138352X)de
dc.identifier.ppn830084118


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