Auswirkung der vertikalen Ganzkörpervibration unterschiedlicher Frequenzen auf die Muskulatur im osteoporotischen Rattenmodell

Ammon, Jan-Christoph

dc.contributor.advisor	Sehmisch, Stephan PD Dr.
dc.contributor.author	Ammon, Jan-Christoph
dc.date.accessioned	2015-07-28T06:49:07Z
dc.date.available	2015-08-05T22:50:10Z
dc.date.issued	2015-07-28
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0022-6063-5
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5197
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Auswirkung der vertikalen Ganzkörpervibration unterschiedlicher Frequenzen auf die Muskulatur im osteoporotischen Rattenmodell	de
dc.type	doctoralThesis	de
dc.title.translated	Effect of vertical whole body vibration with different frequencies on muscle tissue in ovariectomized rats	de
dc.contributor.referee	Wuttke, Wolfgang Prof. Dr.
dc.date.examination	2015-07-29
dc.description.abstracteng	Sarcopenia and osteoporosis are closely associated due to the influence of muscle on bone tissue. Various whole body vibration (WBV) therapy regimens are used for muscle and bone improvement. To identify the effect of different WBV frequencies on muscle, ovariectomized (OVX) rats underwent vertical WBV for 30 days, 15 minutes per day. For this, the rats were divided into six groups according to their treatment regimen: non-OVX group without vibration, OVX group without vibration, and four OVX groups of rats which were treated with different frequencies of WBV (OVX + 35 Hz, OVX + 50 Hz, OVX + 70 Hz, OVX + 90 Hz). For enzyme histochemistry, the gastrocnemius, the longissimus and the soleus muscle of each rat were collected. In the muscles, capillary density and cross sectional areas were analyzed and correlated to the vibration frequency. The results showed no significant increase in capillary density for the four WBV frequencies. The comparison of the different muscles and frequencies indicated a minimum, yet inhomogeneously spread proliferation of the capillary density. Muscle cross sectional areas of the OVX + 35 Hz and OVX + 70 Hz group showed a slight increase without statistically significant differences. Current data on WBV in rat and mouse models assume that lower vibration frequencies might be favorable for muscle and bone improvement. However, further investigations are required, to identify the appropriate WBV regimen for prophylaxis and therapy of sarcopenia and osteoporosis.	de
dc.contributor.coReferee	Schön, Margarete Prof. Dr.
dc.subject.ger	Sarkopenie	de
dc.subject.ger	Ganzkörpervibration	de
dc.subject.ger	Osteoporose	de
dc.subject.ger	ovariektomierte Ratten	de
dc.subject.eng	sarcopenia	de
dc.subject.eng	whole body vibration	de
dc.subject.eng	osteoporosis	de
dc.subject.eng	ovariectomized rats	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0022-6063-5-3
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Orthopädie (PPN619876204)	de
dc.description.embargoed	2015-08-05
dc.identifier.ppn	832242225

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Human- und Zahnmedizin [2872]

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