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dc.contributor.advisor Kermer, Pawel Prof. Dr.
dc.contributor.author Maier, Ilko
dc.date.accessioned 2013-12-20T11:04:42Z
dc.date.available 2014-01-27T23:50:04Z
dc.date.issued 2013-12-20
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-0022-60A6-F
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc 610 de
dc.title Risikoprädiktion für sehr frühen Reinfarkt, Tod und Progression nach ischämischem Schlaganfall de
dc.type doctoralThesis de
dc.title.translated Risk prediction of very early recurrence, death and progression after acute ischaemic stroke de
dc.contributor.referee Kermer, Pawel Prof. Dr.
dc.date.examination 2014-01-20
dc.description.abstracteng Background: Early recurrent strokes lead to extended hospitalization and high number of complications. We investigated three stroke scores, the Essen Stroke Risk Score, the ABCD² and the Recurrence Risk Estimator for their prognostic value to predict early recurrent stroke, death and progressive stroke. Methods: Clinical and radiological data from 1727 consecutive patients with ischemic stroke, being admitted to the stroke unit, were evaluated retrospectively. Predictive value of stroke scores was tested for early recurrence within 7 days, death and progressive stroke expressed as observational risk and area under the receiver operator curve (AUROC). Results: Early recurrent stroke occurred in 56 patients (3.2%), 40 patients (2.3%) died within the first 7 days and 125 patients (7.2%) had a progressive stroke. Essen Stroke Risk Score was not predictive for early recurrence, death or progressive stroke. ABCD² score was predictive for death (p<0.01; χ²; AUROC, 0.65; 0.58 to 0.72), and progressive stroke (p<0.001; χ²; AUROC, 0.70; 0.66 to 0.74). Recurrence Risk Estimator predicted early recurrent stroke (p<0.001; χ²; AUROC, 0.65; 0.58 to 0.73), early death (p<0.001; χ²; AUROC, 0.72; 0.66 to 0.78) and progressive stroke (p<0.001; χ²; AUROC, 0.66; 0.61 to 0.71). Conclusions: Recurrence Risk Estimator bears high potential to not only predict early recurrence but also death and progression after ischemic stroke. ABCD² appears to be useful to predict risk of death and progression. These findings have relevant clinical implications for early triage of patients being admitted to stroke units. de
dc.contributor.coReferee Hilgers, Reinhard Prof. Dr.
dc.contributor.thirdReferee Mausberg, Rainer Prof. Dr.
dc.subject.ger Ischämischer Schlaganfall de
dc.subject.ger Frühe Reischämie de
dc.subject.ger Essen Stroke Risk Score de
dc.subject.ger ABCD² de
dc.subject.ger RRE-90 de
dc.subject.eng Early recurrence de
dc.subject.eng Ischemic stroke de
dc.subject.eng Essen Stroke Risk Score de
dc.subject.eng ABCD² de
dc.subject.eng RRE-90 de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-0022-60A6-F-2
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull GOK-MEDIZIN de
dc.subject.gokfull Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247) de
dc.description.embargoed 2014-01-27
dc.identifier.ppn 775146242

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