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dc.contributor.advisor Borg-von Zepelin, Margarete Prof. Dr. Dr.
dc.contributor.author Kahl, Daniel
dc.date.accessioned 2015-09-02T10:57:08Z
dc.date.available 2015-09-16T22:50:05Z
dc.date.issued 2015-09-02
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-0023-3DA0-D
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Zur Situation invasiver Candidosen in Deutschland de
dc.title.alternative Epidemiologie, Resistenzverhalten und klinisch-geographische Besonderheiten de
dc.type doctoralThesis de
dc.title.translated About situation of invasive candidiasis in germany de
dc.contributor.referee Mörer, Onnen Prof. Dr.
dc.date.examination 2015-09-09
dc.description.abstracteng 657 candida isolates of primary sterile materials of 63 MykolabNet-D member institutes from september 2005 to december 2006 were analysed regarding the nationwide epidemiology, resistance behavior and local and geographic particularities. C. albicans was the dominating species with about 62%, followed by the Non-albicans species (NAC) C. glabrata (18,3%), C.tropicalis (6,1%), C. parapsilosis (5,3%) and C. krusei (2,6%). 68% were blood culture isolates. The most important risk factor was intensive care therapy. 58% of patients were men with an average age of 61 years. C. glabrata- and C. tropicalis-infections seemed to be associated with higher, C. parapsilosis and C. krusei with lower age. Using the CLSI-Standard M27 A2 for broth microdilution testing we analysed sensitivity and MIC90 towards amphotericine B, flucytosine, fluconazole, itraconazole, voriconazole and caspofungine. All isolates were sensitive towards amphothericine, MIC90 was 1,0µg/ml. 91,5%, of the isolates were sensitive towards flucytosine, MIC90 was <0,125 µg/ml. 95,8%, 28,5% and 98,8% of the isolates were sensitive towards fluconazole, itraconazole and voriconazole, MIC90 were 4,0µg/ml, 1,0 µg/ml and 0,125 µg/ml. The sensitivity towards caspofungine was 78,2%, MIC90 0,5µg/ml. We also analysed differences in species distribution and resistance between new and old german states, university and peripheral hospitals and at last different institutions: NAC rate and resistance was significantly higher in the new german states and university hospitals. But the biggest bandwidth we found in the interinstitutional comparison: The rate of C. albicans and C. glabrata differ about 26 and 24%. Local accumulation of resistant strains and species also resulted in strongly differing resistance samples for flucytosine (0-20% resistant C.albicans), fluconazole (0-14% resistant C.glabrata) and caspofungine (0-57% resistant. C.glabrata). The knowledge of the local epidemiology and resistance behavior seems to be imperative for an effective empirical therapy. de
dc.contributor.coReferee Spreer, Annette PD Dr.
dc.title.alternativeTranslated epidemiology, resistance behavior and clinical geographic particularities de
dc.subject.ger invasive Candidiasis de
dc.subject.ger Candidämie de
dc.subject.ger Epidemiologie de
dc.subject.ger Resistenzverhalten de
dc.subject.eng candidiasis de
dc.subject.eng candidemia de
dc.subject.eng epidemiology de
dc.subject.eng resistance behavior de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-0023-3DA0-D-8
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Medizinische Mikrobiologie / Medizinische Virologie / Medizinische Mykologie / Infektionskrankheiten / Hygiene / Impfung / Parasitologie / Tropenmedizin - Allgemein- und Gesamtdarstellungen (PPN619875356) de
dc.description.embargoed 2015-09-16
dc.identifier.ppn 834443058

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