Molecular studies of the synaptic protein otoferlin

Müller, Alexandra

dc.contributor.advisor	Reisinger, Ellen Dr.
dc.contributor.author	Müller, Alexandra
dc.date.accessioned	2017-02-24T10:27:15Z
dc.date.available	2017-02-24T10:27:15Z
dc.date.issued	2017-02-24
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0023-3DB5-0
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6128
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6128
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6128
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Molecular studies of the synaptic protein otoferlin	de
dc.type	doctoralThesis	de
dc.contributor.referee	Brose, Nils Prof. Dr.
dc.date.examination	2016-04-08
dc.description.abstracteng	Deafness is an interesting and intensely studied topic and can be caused by different, genetic as well as environmental, factors. One important cause of deafness are mutations in the otoferlin gene leading to non-syndromic deafness DFNB9. Interestingly, some mutations lead to temperature induced hearing loss where patients have normal to impaired hearing when their body temperature is normal but become deaf as soon as they become febrile. Different mutations of otoferlin were analyzed using biolystic transfection, mass spectrometry, real-time PCR and fluorescence microscopy were used.	de
dc.contributor.coReferee	Dresbach, Thomas Prof. Dr.
dc.contributor.thirdReferee	Göpfert, Martin Prof. Dr.
dc.contributor.thirdReferee	Rizzoli, Silvio Prof. Dr.
dc.contributor.thirdReferee	Schmidt, Manuela Dr.
dc.subject.eng	Otoferlin	de
dc.subject.eng	Hearing	de
dc.subject.eng	Gene Gun	de
dc.subject.eng	Temperature sensitivity	de
dc.subject.eng	Real-time PCR	de
dc.subject.eng	Cloning	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0023-3DB5-0-4
dc.affiliation.institute	Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)	de
dc.subject.gokfull	Biologie (PPN619462639)	de
dc.identifier.ppn	880905301

Files in this item

Name:Dissertation A.Müller_publish2017.pdf

Size:4.528Mb

Format:PDF

View/Open

Name:: Dissertation A.Müller_publish2 ...
Size:: 4.528Mb
Format:: PDF

View/Open

This item appears in the following Collection(s)

GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften [1183]
GGNB - Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences

Show simple item record