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Evaluation eines Echtzeit-Verfahrens in der kardialen Magnetresonanztomographie bei Patienten mit Herzrhytmusstörungen am Beispiel von Vorhofflimmern

dc.contributor.advisorUnterberg-Buchwald, Christina Prof. Dr.
dc.contributor.authorvon Loesch, Eckhart Thassilo
dc.date.accessioned2017-03-06T07:30:03Z
dc.date.available2017-03-16T23:50:06Z
dc.date.issued2017-03-06
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0023-3DC8-6
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-6145
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610de
dc.titleEvaluation eines Echtzeit-Verfahrens in der kardialen Magnetresonanztomographie bei Patienten mit Herzrhytmusstörungen am Beispiel von Vorhofflimmernde
dc.typedoctoralThesisde
dc.title.translatedReal-time-MRI and cardiac arrhythmia - evaluation of a new real-time-reconstruction in patients with atrial fibrillationde
dc.contributor.refereeUnterberg-Buchwald, Christina Prof. Dr.
dc.date.examination2017-03-09
dc.description.abstractengCardiac MRI is regarded as gold-standard for analysis of left ventricular function. Commonly used CINE-SSFP is based on an interpolation of image data, which are acquired from several heart beats. This method is well established for patients in sinus-rhythm. In patients with cardiac arrhythmia it struggles because correlation of acquired data to the right cardiac phase is impeded. A new real-time-MRI-method with a temporal resolution of 40 ms (Real-Time-SSFP) is able to acquire images of cardiac movement consecutively. Image data from 30 patients with atrial fibrillation (AF) during MRI-scan were gained with both CINE-SSFP and Real-Time-SSFP. Additionally each patient obtained transthoracic echocardiography. Image quality of CINE-and Real-Time-MRI-images was scored by two independent observers on a scale from 0 (no diagnostic quality) to 4 (optimal diagnostic quality). To aquire data for cardiac function, images were evaluated with QMass MR (7.4.14.0 – real-time prototype, Medis medical imaging systems bv, Leiden, the Netherlands). The results were used for a comparison between CINE- and Real-Time-MRI. Additionaly both methods were compared with data acquired from echocardiography. Furthermore real-time data offered the possibility to perform a two-dimensional beat-to-beat-analysis in four-chamber-view and to calculate bandwith of ejection fraction. The quality-analysis gave significantly better results for real-time-SSFP than for CINE-SSFP. Due to reduced image-quality more than 10% of CINE-SSFP-images were not congenial for functional analysis. Comparison of functional parameters showed only slight differences between both MRI-methods, although Real-Time-MRI demonstrated a tendency to measure lower values. Real-Time-SSFP differed sligltly lower from echocardiography then CINE-SSFP. This survey showed that Real-Time-SSFP offers the possibility to get images with high diagnostic quality from patients with AF. The new method was also superior for functional analysis. The next task is to enhance segmentation software so that it can be easier used in clinical practice. For three-dimensional real-time-volumetry three dimensional data-acquisition is necessary – one of the biggest challenges in MRI-research. Further applications for Real-Time-MRI in patients with arrhythmia now can be evaluated.de
dc.contributor.coRefereeSigler, Matthias Prof. Dr.
dc.subject.gerMRTde
dc.subject.gerReal-Time-MRTde
dc.subject.gerEchtzeit-MRTde
dc.subject.gerHerzrhythmusstörungende
dc.subject.gerVorhofflimmernde
dc.subject.gerCINE-SSFPde
dc.subject.gerSSFPde
dc.subject.gerbSSFPde
dc.subject.gerQualitätsanalysede
dc.subject.gerHerzfunktionde
dc.subject.gerLotzde
dc.subject.engmride
dc.subject.engarrhythmiade
dc.subject.engreal-time-mride
dc.subject.engatrial fibrillationde
dc.subject.engCINEde
dc.subject.engCINE-SSFPde
dc.subject.engSSFPde
dc.subject.engcardiac functionde
dc.subject.engquality analysisde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0023-3DC8-6-2
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.subject.gokfullKardiologie (PPN619875755)de
dc.subject.gokfullRadiologiede
dc.subject.gokfullBildgebende Verfahrende
dc.subject.gokfullUltraschallde
dc.subject.gokfullNuklearmedizinde
dc.subject.gokfullStrahlenschutz - Allgemein- und Gesamtdarstellungen (PPN619875585)de
dc.description.embargoed2017-03-16
dc.identifier.ppn881428299


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