Das purinerge System im vorderen Telenzephalon der Kaulquappe von Xenopus laevis und dessen Beteiligung an der Verarbeitung von Duftstoffantworten

Das purinerge System im vorderen Telenzephalon der Kaulquappe von Xenopus laevis und dessen Beteiligung an der Verarbeitung von Duftstoffantworten

The purinergic system in the anterior telencephalon of the tadpole of Xenopus laevis and its involvement in the processing of odorants.

Anna Peters

Doctoral thesis

Date of Examination: 2017-03-15

Date of issue: 2017-03-08

Advisor: Schild, Detlev Prof. Dr. Dr.

Referee: Lutz, Susanne Prof. Dr.

Referee: Schön, Margarete Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-0023-3DCA-2

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Abstract

English

The anterior part of the telencephalon of Xenopus laevis consists mainly of the olfactory bulb and the lateral ventricles which expand deep into the anterior telencephalon. The periventricular zone generates new olfactory bulb neurons throughout lifetime. Extracellular nucleotides act via purinergic receptors, which have been divided into two families: metabotropic adenosine or P1-receptors and ionotropic P2X plus metabotropic P2Y receptors. Cells of the olfactory bulb almost exclusively express ionotropic P2X subtypes, whereas periventricular cells express both, P1, P2X and P2Y receptors. In the present study I identified and characterized the purinergic system of the olfactory bulb and the periventricular zone. Within a time period of 24 hours 42, 54 ± 6, 65% of all periventricular cells were actively proliferating, which is surprisingly high. There are positive P2X7-stainings in the olfactory bulb and the periventricular zone; P2X4 receptors are mainly located in the periventricular zone. The P2X-receptors expressed in the olfactory bulb are evidently not involved in the immediate processing of olfactory information.

Keywords: P1 receptor; P2 receptor; periventricular zone; Olfaction

Schlagwörter: P1-Rezeptor; P2-Rezeptor; Periventrikuläre Zone; Geruchssinn