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dc.contributor.advisor Schild, Detlev Prof. Dr. Dr.
dc.contributor.author Peters, Anna
dc.date.accessioned 2017-03-08T09:32:41Z
dc.date.available 2017-03-22T23:50:05Z
dc.date.issued 2017-03-08
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-0023-3DCA-2
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Das purinerge System im vorderen Telenzephalon der Kaulquappe von Xenopus laevis und dessen Beteiligung an der Verarbeitung von Duftstoffantworten de
dc.type doctoralThesis de
dc.title.translated The purinergic system in the anterior telencephalon of the tadpole of Xenopus laevis and its involvement in the processing of odorants. de
dc.contributor.referee Lutz, Susanne Prof. Dr.
dc.date.examination 2017-03-15
dc.description.abstracteng The anterior part of the telencephalon of Xenopus laevis consists mainly of the olfactory bulb and the lateral ventricles which expand deep into the anterior telencephalon. The periventricular zone generates new olfactory bulb neurons throughout lifetime. Extracellular nucleotides act via purinergic receptors, which have been divided into two families: metabotropic adenosine or P1-receptors and ionotropic P2X plus metabotropic P2Y receptors. Cells of the olfactory bulb almost exclusively express ionotropic P2X subtypes, whereas periventricular cells express both, P1, P2X and P2Y receptors. In the present study I identified and characterized the purinergic system of the olfactory bulb and the periventricular zone. Within a time period of 24 hours 42, 54 ± 6, 65% of all periventricular cells were actively proliferating, which is surprisingly high. There are positive P2X7-stainings in the olfactory bulb and the periventricular zone; P2X4 receptors are mainly located in the periventricular zone. The P2X-receptors expressed in the olfactory bulb are evidently not involved in the immediate processing of olfactory information. de
dc.contributor.coReferee Schön, Margarete Prof. Dr.
dc.subject.ger P1-Rezeptor de
dc.subject.ger P2-Rezeptor de
dc.subject.ger Periventrikuläre Zone de
dc.subject.ger Geruchssinn de
dc.subject.eng P1 receptor de
dc.subject.eng P2 receptor de
dc.subject.eng periventricular zone de
dc.subject.eng Olfaction de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-0023-3DCA-2-4
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Medizin (PPN619874732) de
dc.subject.gokfull Neuroanatomie, Neurophysiologie, Neuropathologie (PPN619876255) de
dc.description.embargoed 2017-03-22
dc.identifier.ppn 88165244X

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