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Das purinerge System im vorderen Telenzephalon der Kaulquappe von Xenopus laevis und dessen Beteiligung an der Verarbeitung von Duftstoffantworten

dc.contributor.advisorSchild, Detlev Prof. Dr. Dr.
dc.contributor.authorPeters, Anna
dc.titleDas purinerge System im vorderen Telenzephalon der Kaulquappe von Xenopus laevis und dessen Beteiligung an der Verarbeitung von Duftstoffantwortende
dc.title.translatedThe purinergic system in the anterior telencephalon of the tadpole of Xenopus laevis and its involvement in the processing of
dc.contributor.refereeLutz, Susanne Prof. Dr.
dc.description.abstractengThe anterior part of the telencephalon of Xenopus laevis consists mainly of the olfactory bulb and the lateral ventricles which expand deep into the anterior telencephalon. The periventricular zone generates new olfactory bulb neurons throughout lifetime. Extracellular nucleotides act via purinergic receptors, which have been divided into two families: metabotropic adenosine or P1-receptors and ionotropic P2X plus metabotropic P2Y receptors. Cells of the olfactory bulb almost exclusively express ionotropic P2X subtypes, whereas periventricular cells express both, P1, P2X and P2Y receptors. In the present study I identified and characterized the purinergic system of the olfactory bulb and the periventricular zone. Within a time period of 24 hours 42, 54 ± 6, 65% of all periventricular cells were actively proliferating, which is surprisingly high. There are positive P2X7-stainings in the olfactory bulb and the periventricular zone; P2X4 receptors are mainly located in the periventricular zone. The P2X-receptors expressed in the olfactory bulb are evidently not involved in the immediate processing of olfactory
dc.contributor.coRefereeSchön, Margarete Prof. Dr.
dc.subject.gerPeriventrikuläre Zonede
dc.subject.engP1 receptorde
dc.subject.engP2 receptorde
dc.subject.engperiventricular zonede
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.subject.gokfullNeuroanatomie, Neurophysiologie, Neuropathologie (PPN619876255)de

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