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dc.contributor.advisor Dressel, Ralf Prof. Dr.
dc.contributor.author Johannsen, Hannah
dc.date.accessioned 2017-03-22T14:32:11Z
dc.date.available 2017-04-06T22:50:06Z
dc.date.issued 2017-03-22
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-0023-3DE8-D
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Suszeptibilität parthenogenetischer Stammzellen und ihrer Derivate gegenüber zytotoxischen Effektormechanismen de
dc.type doctoralThesis de
dc.title.translated Susceptibility of parthenogenetic stem cells and their derivates to cytotoxic effector mechanisms de
dc.contributor.referee Dressel, Ralf Prof. Dr.
dc.date.examination 2017-08-17
dc.description.abstracteng Parthenogenetic stem cells may provide an attractive new source in regenerative medicine. As their major histocompability complex (MHC) ist haploidentical, PSC-banks may offer ready access to MHC-matched allogeneic stem cells. In this doctoral thesis their immunological properties were examined. PSC were largely resistant to CTLs derived from T-cell-receptor transgenic OT-I mice. However, it was shown that as undifferentiated PSC lack MHC-class-I-molecules and present various activating ligands on their surface, they are readily recognized and killed by NK-cell mediated effector mechanisms. Once further differentiated, PSC grew more resistant as a decrease in activating ligands, e.g. Rae-1, CD 112 and CD155, was observed. This might prove beneficial in a transplantational setting as residues of potentially tumorigenic undifferentiated cells could be eliminated by the host's immune response. de
dc.contributor.coReferee Wulf, Gerald Prof. Dr.
dc.subject.ger Parthenogenetische Stammzellen de
dc.subject.ger Zytotoxische Effektormechanismen de
dc.subject.ger Natürliche Killerzellen de
dc.subject.ger Zytotoxische T-Zellen de
dc.subject.eng parthenogenetic stem cells de
dc.subject.eng natural killer cells de
dc.subject.eng cytotoxic T lymphocytes de
dc.subject.eng NK cell receptor ligands de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-0023-3DE8-D-3
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Immunologie / Allergologie / Umweltmedizin / Medizinische Ökologie - Allgemein- und Gesamtdarstellungen (PPN619875445) de
dc.description.embargoed 2017-04-06
dc.identifier.ppn 882802011

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