dc.contributor.advisor | Dressel, Ralf Prof. Dr. | |
dc.contributor.author | Johannsen, Hannah | |
dc.date.accessioned | 2017-03-22T14:32:11Z | |
dc.date.available | 2017-04-06T22:50:06Z | |
dc.date.issued | 2017-03-22 | |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0023-3DE8-D | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-6211 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-6211 | |
dc.language.iso | deu | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Suszeptibilität parthenogenetischer Stammzellen und ihrer Derivate gegenüber zytotoxischen Effektormechanismen | de |
dc.type | doctoralThesis | de |
dc.title.translated | Susceptibility of parthenogenetic stem cells and their derivates to cytotoxic effector mechanisms | de |
dc.contributor.referee | Dressel, Ralf Prof. Dr. | |
dc.date.examination | 2017-08-17 | |
dc.description.abstracteng | Parthenogenetic stem cells may provide an attractive new source in regenerative medicine. As their major histocompability complex (MHC) ist haploidentical, PSC-banks may offer ready access to MHC-matched allogeneic stem cells. In this doctoral thesis their immunological properties were examined. PSC were largely resistant to CTLs derived from T-cell-receptor transgenic OT-I mice. However, it was shown that as undifferentiated PSC lack MHC-class-I-molecules and present various activating ligands on their surface, they are readily recognized and killed by NK-cell mediated effector mechanisms. Once further differentiated, PSC grew more resistant as a decrease in activating ligands, e.g. Rae-1, CD 112 and CD155, was observed. This might prove beneficial in a transplantational setting as residues of potentially tumorigenic undifferentiated cells could be eliminated by the host's immune response. | de |
dc.contributor.coReferee | Wulf, Gerald Prof. Dr. | |
dc.subject.ger | Parthenogenetische Stammzellen | de |
dc.subject.ger | Zytotoxische Effektormechanismen | de |
dc.subject.ger | Natürliche Killerzellen | de |
dc.subject.ger | Zytotoxische T-Zellen | de |
dc.subject.eng | parthenogenetic stem cells | de |
dc.subject.eng | natural killer cells | de |
dc.subject.eng | cytotoxic T lymphocytes | de |
dc.subject.eng | NK cell receptor ligands | de |
dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0023-3DE8-D-3 | |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Immunologie / Allergologie / Umweltmedizin / Medizinische Ökologie - Allgemein- und Gesamtdarstellungen (PPN619875445) | de |
dc.description.embargoed | 2017-04-06 | |
dc.identifier.ppn | 882802011 | |