Zur Kurzanzeige

Suszeptibilität parthenogenetischer Stammzellen und ihrer Derivate gegenüber zytotoxischen Effektormechanismen

dc.contributor.advisorDressel, Ralf Prof. Dr.
dc.contributor.authorJohannsen, Hannah
dc.date.accessioned2017-03-22T14:32:11Z
dc.date.available2017-04-06T22:50:06Z
dc.date.issued2017-03-22
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0023-3DE8-D
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-6211
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-6211
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610de
dc.titleSuszeptibilität parthenogenetischer Stammzellen und ihrer Derivate gegenüber zytotoxischen Effektormechanismende
dc.typedoctoralThesisde
dc.title.translatedSusceptibility of parthenogenetic stem cells and their derivates to cytotoxic effector mechanismsde
dc.contributor.refereeDressel, Ralf Prof. Dr.
dc.date.examination2017-08-17
dc.description.abstractengParthenogenetic stem cells may provide an attractive new source in regenerative medicine. As their major histocompability complex (MHC) ist haploidentical, PSC-banks may offer ready access to MHC-matched allogeneic stem cells. In this doctoral thesis their immunological properties were examined. PSC were largely resistant to CTLs derived from T-cell-receptor transgenic OT-I mice. However, it was shown that as undifferentiated PSC lack MHC-class-I-molecules and present various activating ligands on their surface, they are readily recognized and killed by NK-cell mediated effector mechanisms. Once further differentiated, PSC grew more resistant as a decrease in activating ligands, e.g. Rae-1, CD 112 and CD155, was observed. This might prove beneficial in a transplantational setting as residues of potentially tumorigenic undifferentiated cells could be eliminated by the host's immune response.de
dc.contributor.coRefereeWulf, Gerald Prof. Dr.
dc.subject.gerParthenogenetische Stammzellende
dc.subject.gerZytotoxische Effektormechanismende
dc.subject.gerNatürliche Killerzellende
dc.subject.gerZytotoxische T-Zellende
dc.subject.engparthenogenetic stem cellsde
dc.subject.engnatural killer cellsde
dc.subject.engcytotoxic T lymphocytesde
dc.subject.engNK cell receptor ligandsde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0023-3DE8-D-3
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullImmunologie / Allergologie / Umweltmedizin / Medizinische Ökologie - Allgemein- und Gesamtdarstellungen (PPN619875445)de
dc.description.embargoed2017-04-06
dc.identifier.ppn882802011


Dateien

Thumbnail

Das Dokument erscheint in:

Zur Kurzanzeige