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dc.contributor.advisor Meister, Tobias Prof. Dr.
dc.contributor.author Röming, Alexander Klaus Hermann
dc.date.accessioned 2017-03-24T09:53:50Z
dc.date.available 2017-04-26T22:50:05Z
dc.date.issued 2017-04-26
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-0023-3DEC-5
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Endocuff-assistierte Koloskopie versus Standardkoloskopie zur Detektion von Adenomen – Eine prospektive randomisierte Multicenterstudie – de
dc.type doctoralThesis de
dc.title.translated Higher adenoma detection rates with endocuff-assisted colonoscopy - a randomized controlled multicenter trial de
dc.contributor.referee Müller-Dornieden, Annegret Prof. Dr.
dc.date.examination 2017-04-06
dc.description.abstracteng OBJECTIVES: The Endocuff is a device mounted on the tip of the colonoscope to help flatten the colonic folds during withdrawal. This study aimed to compare the adenoma detection rates between Endocuff-assisted (EC) colonoscopy and standard colonoscopy (SC). METHODS: This randomized prospective multicenter trial was conducted at four academic endoscopy units in Germany. PARTICIPANTS: 500 patients (235 males, median age 64[IQR 54-73]) for colon adenoma detection purposes were included in the study. All patients were either allocated to EC or SC. The primary outcome measure was the determination of the adenoma detection rates (ADR). RESULTS: The ADR significantly increased with the use of the Endocuff compared to standard colonoscopy (35.4%[95% confidence interval{CI} 29-41%] vs. 20.7%[95%CI 15-26%], p<0.0001). Significantly more sessile polyps were detected by EC. Overall procedure time and withdrawal time did not differ. Caecal and ileum intubation rates were similar. No major adverse events occurred in both groups. In multivariate analysis, age (odds ratio [OR] 1.03; 95%[CI] 1.01-1.05), male sex (OR 1.74; 95%CI 1.10-2.73), withdrawal time (OR 1.16; 95%CI 1.05-1.30), procedure time (OR 1.07; 95%CI 1.04-1.10), colon cleanliness (OR 0.60; 95%CI 0.39-0.94) and use of Endocuff (OR 2.09; 95%CI 1.34-3.27) were independent predictors of adenoma detection rates. CONCLUSIONS: EC increases the adenoma detection rate by 14.7%(95%CI 6.9-22.5%). EC is safe, effective, easy to handle and might reduce colorectal interval carcinomas. de
dc.contributor.coReferee Meyer, Thomas Prof. Dr.
dc.subject.eng Adenoma detection rate de
dc.subject.eng Endocuff de
dc.subject.eng Colonoscopy de
dc.subject.eng ADR de
dc.subject.eng withdrawel time de
dc.subject.eng Polyp detection rate de
dc.subject.eng PDR de
dc.subject.eng colorectal interval carcinomas de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-0023-3DEC-5-3
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Medizin (PPN619874732) de
dc.description.embargoed 2017-12-31
dc.identifier.ppn 882960105

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