Endocuff-assistierte Koloskopie versus Standardkoloskopie zur Detektion von Adenomen – Eine prospektive randomisierte Multicenterstudie –

Röming, Alexander Klaus Hermann

dc.contributor.advisor	Meister, Tobias Prof. Dr.
dc.contributor.author	Röming, Alexander Klaus Hermann
dc.date.accessioned	2017-03-24T09:53:50Z
dc.date.available	2017-04-26T22:50:05Z
dc.date.issued	2017-04-26
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0023-3DEC-5
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6198
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Endocuff-assistierte Koloskopie versus Standardkoloskopie zur Detektion von Adenomen – Eine prospektive randomisierte Multicenterstudie –	de
dc.type	doctoralThesis	de
dc.title.translated	Higher adenoma detection rates with endocuff-assisted colonoscopy - a randomized controlled multicenter trial	de
dc.contributor.referee	Müller-Dornieden, Annegret Prof. Dr.
dc.date.examination	2017-04-06
dc.description.abstracteng	OBJECTIVES: The Endocuff is a device mounted on the tip of the colonoscope to help flatten the colonic folds during withdrawal. This study aimed to compare the adenoma detection rates between Endocuff-assisted (EC) colonoscopy and standard colonoscopy (SC). METHODS: This randomized prospective multicenter trial was conducted at four academic endoscopy units in Germany. PARTICIPANTS: 500 patients (235 males, median age 64[IQR 54-73]) for colon adenoma detection purposes were included in the study. All patients were either allocated to EC or SC. The primary outcome measure was the determination of the adenoma detection rates (ADR). RESULTS: The ADR significantly increased with the use of the Endocuff compared to standard colonoscopy (35.4%[95% confidence interval{CI} 29-41%] vs. 20.7%[95%CI 15-26%], p<0.0001). Significantly more sessile polyps were detected by EC. Overall procedure time and withdrawal time did not differ. Caecal and ileum intubation rates were similar. No major adverse events occurred in both groups. In multivariate analysis, age (odds ratio [OR] 1.03; 95%[CI] 1.01-1.05), male sex (OR 1.74; 95%CI 1.10-2.73), withdrawal time (OR 1.16; 95%CI 1.05-1.30), procedure time (OR 1.07; 95%CI 1.04-1.10), colon cleanliness (OR 0.60; 95%CI 0.39-0.94) and use of Endocuff (OR 2.09; 95%CI 1.34-3.27) were independent predictors of adenoma detection rates. CONCLUSIONS: EC increases the adenoma detection rate by 14.7%(95%CI 6.9-22.5%). EC is safe, effective, easy to handle and might reduce colorectal interval carcinomas.	de
dc.contributor.coReferee	Meyer, Thomas Prof. Dr.
dc.subject.eng	Adenoma detection rate	de
dc.subject.eng	Endocuff	de
dc.subject.eng	Colonoscopy	de
dc.subject.eng	ADR	de
dc.subject.eng	withdrawel time	de
dc.subject.eng	Polyp detection rate	de
dc.subject.eng	PDR	de
dc.subject.eng	colorectal interval carcinomas	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0023-3DEC-5-3
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.description.embargoed	2017-12-31
dc.identifier.ppn	882960105

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Human- und Zahnmedizin [2872]

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