Differenzielle Expression proatherogener Zellmarker auf Monozytensubpopulationen bei Patienten mit stabiler koronarer Herzkrankheit

Differenzielle Expression proatherogener Zellmarker auf Monozytensubpopulationen bei Patienten mit stabiler koronarer Herzkrankheit

Differential expression of proatherogenic cell markers on monocyte subpopulations of patients with stable coronary artery disease

Hendrik Kuschicke

Doctoral thesis

Date of Examination: 2017-03-30

Date of issue: 2017-03-29

Advisor: Czepluch, Frauke Stefanie PD Dr.

Referee: Czepluch, Frauke Stefanie PD Dr.

Referee: Oppermann, Martin Prof. Dr.

Referee: Meyer, Thomas Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-0023-3DF4-2

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Abstract

English

Monocytes and platelets are important cellular mediators of atherosclerosis. Human monocytes can be divided into CD14++CD16− , CD14++CD16+ and CD14+CD16++ cells, which differ in their functional properties. The aim of this thesis was to examine monocyte subset distribution, monocyte-platelet aggregate (MPA) formation, expression of CCR5, the receptor of the platelet-derived chemokine CCL5, of OPN receptor CD44, monocyte migration chemokine, of KLF4, an atheroprotective protein, and other soluble chemokines, to determine whether these parameters are altered in individuals with coronary atherosclerosis.

Keywords: coronary artery disease; monocyte subsets; monocyte subpopulations; MPA; OPN; CCR5; CCL5; RANTES